Glucosylceramide synthetase inhibitors sensitise B-CLL cells to cytotoxic agents without reversing P-gp functional activity.

Glucosylceramide synthetase inhibitors sensitise B-CLL cells to cytotoxic agents without reversing P-gp functional activity.

Bibliographic Details
Main Authors:	Gerrard, G, Butters, T, Mehta, AB, Hoffbrand, A, Hughes, D, Burgess, M, Ganeshaguru, K
Format:	Conference item
Published:	2004

Similar Items

Glucosylceramide synthase inhibitors sensitise CLL cells to cytotoxic agents without reversing P-gp functional activity.
by: Gerrard, G, et al.
Published: (2009)

Inhibition of glucosylceramide synthase does not reverse drug resistance in cancer cells.
by: Norris-Cervetto, E, et al.
Published: (2004)

Glucosylceramide flippases contribute to cellular glucosylceramide homeostasis
by: Natsuki Kita, et al.
Published: (2024-03-01)

Glucosylceramide modulates membrane traffic along the endocytic pathway.
by: Sillence, D, et al.
Published: (2002)

Glucosylceramide modulates membrane traffic along the endocytic pathway
by: Dan J. Sillence, et al.
Published: (2002-11-01)

Property-based design of a glucosylceramide synthase inhibitor that reduces glucosylceramide in the brain
by: Scott D. Larsen, et al.
Published: (2012-02-01)

Can P-glycoprotein influence the bioavailability of iminosugar-based glucosylceramide synthase inhibitors?
by: Norris-Cervetto, E, et al.
Published: (2006)

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease
by: Boucheron, C, et al.
Published: (2005)

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells
by: Yong-Yu Liu, et al.
Published: (2004-05-01)

Accumulation of glucosylceramide in murine testis, caused by inhibition of beta-glucosidase 2: implications for spermatogenesis.
by: Walden, C, et al.
Published: (2007)

Defining the glucosylceramide population of C. elegans
by: Mark A. Xatse, et al.
Published: (2023-09-01)

Synthesis and biological properties of fungal glucosylceramide.
by: Maurizio Del Poeta, et al.
Published: (2014-01-01)

Glucosylceramides of pig epidermis: structure determination.
by: P W Wertz, et al.
Published: (1983-09-01)

Central sensitisation: causes, therapies, and terminology
by: Mehta, P, et al.
Published: (2021)

New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase.
by: Li, H, et al.
Published: (2008)

Ceramides and glucosylceramides are independent antagonists of insulin action
by: Chavez Jose A, et al.
Published: (2012-06-01)

Correction: synthesis and biological properties of fungal glucosylceramide.
by: Maurizio Del Poeta, et al.
Published: (2015-05-01)

Quantification of glucosylceramide in plasma of Gaucher disease patients
by: Maria Viviane Gomes Muller, et al.
Published: (2010-12-01)

Ubiquitous transgene expression of the glucosylceramide-synthesizing enzyme accelerates glucosylceramide accumulation and storage cells in a Gaucher disease mouse model.
by: Sonya Barnes, et al.
Published: (2014-01-01)

Design and synthesis of iminosugar-based inhibitors of glucosylceramide synthase: the search for new therapeutic agents against Gaucher disease (vol 16, pg 1747, 2005)
by: Boucheron, C, et al.
Published: (2005)

Chimeric human opsins as optogenetic light sensitisers
by: Hickey, D, et al.
Published: (2021)

Characterization of glucosylceramides in Pseudallescheria boydii and their involvement in fungal differentiation.
by: Pinto, MR, et al.
Published: (2002)

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide.
by: D'Angelo, G, et al.
Published: (2007)

Synthesis of a novel photoactivatable glucosylceramide cross-linker
by: Monique Budani, et al.
Published: (2016-09-01)

Monoclonal antibody specific to glucosylceramide found in pathogenic fungi
by: MS Toledo, et al.
Published: (2000-03-01)

Glucosylceramide synthase maintains influenza virus entry and infection.
by: Kelly Drews, et al.
Published: (2020-01-01)

The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.
by: Smith, D, et al.
Published: (2006)

Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease
by: Valentina Rubino, et al.
Published: (2023-05-01)

Glycosphingolipid changes in plasma in Parkinson’s disease independent of glucosylceramide levels
by: te Vruchte, D, et al.
Published: (2022)

Glucosylceramide Synthase Is Involved in Development of Invariant Natural Killer T Cells
by: Zoran V. Popovic, et al.
Published: (2017-07-01)

Free ceramide, sphingomyelin, and glucosylceramide of isolated rat intestinal cells.
by: J F Bouhours, et al.
Published: (1979-09-01)

Glucosylceramide acyl chain length is sensed by the glycolipid transfer protein.
by: Anders P E Backman, et al.
Published: (2018-01-01)

Glucosylceramide synthase in the fat body controls energy metabolism in Drosophila[S]
by: Ayako Kohyama-Koganeya, et al.
Published: (2011-07-01)

Glucosylceramide Administration as a Vaccination Strategy in Mouse Models of Cryptococcosis.
by: Visesato Mor, et al.
Published: (2016-01-01)

ARF6 regulates neuron differentiation through glucosylceramide synthase.
by: Lu Li, et al.
Published: (2013-01-01)

Elective sensitisation (an experimental attempt)
by: Gupta J, et al.
Published: (1972-01-01)

Hibiscus flower extract as a natural dye sensitiser for a dye-sensitised solar cell
by: Rachel Fran Mansa, et al.
Published: (2014)

Glucosylceramides from <i>Cladosporium</i> and Their Roles in Fungi–Plant Interaction
by: Mariana Ingrid Dutra da Silva Xisto, et al.
Published: (2022-06-01)

Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion
by: Tian Xia, et al.
Published: (2023-03-01)

Glucosylceramide is essential for Heartland and Dabie bandavirus glycoprotein-induced membrane fusion.
by: Tian Xia, et al.
Published: (2023-03-01)