Neuronal computation underlying inferential reasoning in humans and mice
Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events, to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions, however th...
| Hoofdauteurs: | , , , , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
Elsevier
2020
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| _version_ | 1826268397027983360 |
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| author | Barron, H Reeve, HM Koolschijn, RS Perestenko, P Shpektor, A Nili, H Rothaermel, R Campo-Urrizo, N O’Reilly, J Bannerman, D Behrens, T Dupret, D |
| author_facet | Barron, H Reeve, HM Koolschijn, RS Perestenko, P Shpektor, A Nili, H Rothaermel, R Campo-Urrizo, N O’Reilly, J Bannerman, D Behrens, T Dupret, D |
| author_sort | Barron, H |
| collection | OXFORD |
| description | Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events, to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions, however the underlying neuronal computation remains unknown. Here we use a multi-day cross-species approach in humans and mice to report the functional anatomy and neuronal computation underlying inferential decisions. We show that during successful inference, the mammalian brain uses a hippocampal prospective code to forecast temporally-structured learned associations. Moreover, during resting behaviour, coactivation of hippocampal cells in sharp-wave/ripples represent inferred relationships that include reward, thereby “joining-the-dots” between events that have not been observed together but lead to profitable outcomes. Computing mnemonic links in this manner may provide an important mechanism to build a cognitive map that stretches beyond direct experience, thus supporting flexible behavior. |
| first_indexed | 2024-03-06T21:09:03Z |
| format | Journal article |
| id | oxford-uuid:3d826cf9-8695-4f88-84a0-c25033098ecb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:09:03Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:3d826cf9-8695-4f88-84a0-c25033098ecb2022-03-26T14:19:46ZNeuronal computation underlying inferential reasoning in humans and miceJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3d826cf9-8695-4f88-84a0-c25033098ecbEnglishSymplectic ElementsElsevier2020Barron, HReeve, HMKoolschijn, RSPerestenko, PShpektor, ANili, HRothaermel, RCampo-Urrizo, NO’Reilly, JBannerman, DBehrens, TDupret, DEvery day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events, to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions, however the underlying neuronal computation remains unknown. Here we use a multi-day cross-species approach in humans and mice to report the functional anatomy and neuronal computation underlying inferential decisions. We show that during successful inference, the mammalian brain uses a hippocampal prospective code to forecast temporally-structured learned associations. Moreover, during resting behaviour, coactivation of hippocampal cells in sharp-wave/ripples represent inferred relationships that include reward, thereby “joining-the-dots” between events that have not been observed together but lead to profitable outcomes. Computing mnemonic links in this manner may provide an important mechanism to build a cognitive map that stretches beyond direct experience, thus supporting flexible behavior. |
| spellingShingle | Barron, H Reeve, HM Koolschijn, RS Perestenko, P Shpektor, A Nili, H Rothaermel, R Campo-Urrizo, N O’Reilly, J Bannerman, D Behrens, T Dupret, D Neuronal computation underlying inferential reasoning in humans and mice |
| title | Neuronal computation underlying inferential reasoning in humans and mice |
| title_full | Neuronal computation underlying inferential reasoning in humans and mice |
| title_fullStr | Neuronal computation underlying inferential reasoning in humans and mice |
| title_full_unstemmed | Neuronal computation underlying inferential reasoning in humans and mice |
| title_short | Neuronal computation underlying inferential reasoning in humans and mice |
| title_sort | neuronal computation underlying inferential reasoning in humans and mice |
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