ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity

Iminosugars have therapeutic potential against a range of diseases, due to their efficacy as glycosidase inhibitors. A major challenge in the development of iminosugar drugs lies in making a compound that is selective for the glycosidase associated with a given disease. We report the synthesis of To...

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Hlavní autoři: Kiappes, JL, Hill, ML, Alonzi, DS, Miller, JL, Iwaki, R, Sayce, AC, Caputo, AT, Kato, A, Zitzmann, N
Médium: Journal article
Jazyk:English
Vydáno: American Chemical Society 2017