ToP-DNJ, a selective inhibitor of endoplasmic reticulum α-glucosidase II exhibiting anti-flaviviral activity
Iminosugars have therapeutic potential against a range of diseases, due to their efficacy as glycosidase inhibitors. A major challenge in the development of iminosugar drugs lies in making a compound that is selective for the glycosidase associated with a given disease. We report the synthesis of To...
Main Authors: | Kiappes, JL, Hill, ML, Alonzi, DS, Miller, JL, Iwaki, R, Sayce, AC, Caputo, AT, Kato, A, Zitzmann, N |
---|---|
Format: | Journal article |
Language: | English |
Published: |
American Chemical Society
2017
|
Similar Items
-
Structural studies of Endoplasmic Reticulum Glucosidase II
by: Caputo, A, et al.
Published: (2015) -
Structural insights into the broad-spectrum antiviral target endoplasmic reticulum alpha-glucosidase II
by: Zitzmann, N, et al.
Published: (2018) -
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4
by: Warfield, KL, et al.
Published: (2016) -
Iminosugars inhibit dengue virus production via inhibition of ER alpha-glucosidases – not glycolipid processing enzymes
by: Sayce, AC, et al.
Published: (2016) -
Pathogen-induced inflammation is attenuated by the iminosugar MON-DNJ via modulation of the unfolded protein response
by: Sayce, AC, et al.
Published: (2021)