Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

Motif inference reveals optimal CTL epitopes presented by HLA class I alleles highly prevalent in southern Africa.

HIV-specific CTL play a central role in immune control of HIV. The basis for understanding the success or failure of this immune response requires identification of the specific epitopes targeted by CTL. However, in populations most severely affected by the global epidemic, this fundamental knowledg...

Full description

Bibliographic Details
Main Authors:	Honeyborne, I, Rathod, A, Buchli, R, Ramduth, D, Moodley, E, Rathnavalu, P, Chetty, S, Day, C, Brander, C, Hildebrand, W, Walker, B, Kiepiela, P, Goulder, P
Format:	Journal article
Language:	English
Published:	2006

Similar Items

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype.
by: Leslie, A, et al.
Published: (2006)

Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype. (vol 177, pg 4699, 2006)
by: Leslie, A, et al.
Published: (2006)

Erratum: Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype (Journal of Immunology (2006) 177 (4699-4708))
by: Leslie, A, et al.
Published: (2006)

Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA.
by: Kiepiela, P, et al.
Published: (2004)

Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.
by: Leslie, A, et al.
Published: (2005)

Mother-to-child transmission of HIV infection and CTL escape through HLA-A2-SLYNTVATL epitope sequence variation.
by: Goulder, P, et al.
Published: (2001)

Identification of dominant optimal HLA-B60- and HLA-B61-restricted cytotoxic T-lymphocyte (CTL) epitopes: rapid characterization of CTL responses by enzyme-linked immunospot assay.
by: Altfeld, M, et al.
Published: (2000)

HIV-1 Escape from an HLA-B*13-Restricted Gag Epitope Affects the Gag-Pol Frameshift Stem-loop and Reduces Viral Fitness
by: Prado, J, et al.
Published: (2008)

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes.
by: Honeyborne, I, et al.
Published: (2007)

Targeting of a CD8 T cell env epitope presented by HLA-B*5802 is associated with markers of HIV disease progression and lack of selection pressure.
by: Ngumbela, K, et al.
Published: (2008)

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.
by: Willberg, C, et al.
Published: (2010)

HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control.
by: Kloverpris, H, et al.
Published: (2012)

Rapid progressing allele HLA-B35 Px restricted anti-HIV-1 CD8+ T cells recognize vestigial CTL epitopes.
by: Christian B Willberg, et al.
Published: (2010-04-01)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection.
by: Crawford, H, et al.
Published: (2007)

Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes.
by: Christian B Willberg, et al.
Published: (2016-01-01)

Provir/Latitude 45 study: A step towards a multi-epitopic CTL vaccine designed on archived HIV-1 DNA and according to dominant HLA I alleles.
by: Camille Tumiotto, et al.
Published: (2019-01-01)

Differential immunogenicity of HIV-1 clade C proteins in eliciting CD8+ and CD4+ cell responses.
by: Ramduth, D, et al.
Published: (2005)

Identification of novel HLA-A2-restricted human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte epitopes predicted by the HLA-A2 supertype peptide-binding motif.
by: Altfeld, M, et al.
Published: (2001)

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.
by: Prado, J, et al.
Published: (2009)

HLA-B63 presents HLA-B57/B58-restricted cytotoxic T-lymphocyte epitopes and is associated with low human immunodeficiency virus load.
by: Frahm, N, et al.
Published: (2005)

Immunodominant HIV-1 Cd4+ T cell epitopes in chronic untreated clade C HIV-1 infection.
by: Ramduth, D, et al.
Published: (2009)

Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restrieted gag epitope in chronic human immunodeficiency virus type 1 infection (vol 81, pg 8346, 2007)
by: Crawford, H, et al.
Published: (2008)

Additive contribution of HLA class I alleles in the immune control of HIV-1 infection.
by: Leslie, A, et al.
Published: (2010)

P09-19 LB. CTL escape mutations in gag epitopes restricted by protective HLA class I alleles cause substantial reductions in viral replication capacity
by: Walker B, et al.
Published: (2009-10-01)

Definition of peptide binding motifs amongst the HLA-A*30 allelic group.
by: Krausa, P, et al.
Published: (2000)

Kinetics of HIV-1 CTL epitopes recognized by HLA I alleles in HIV-infected individuals at times near primary infection: the Provir/Latitude45 study.
by: Jennifer Papuchon, et al.
Published: (2014-01-01)

Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection
by: Bansal, A, et al.
Published: (2009)

HLA-A*0201-restricted CTL epitopes in Rv0350 and Rv0351 of latent Mycobacterium tuberculosis
by: Y. Sun, et al.
Published: (2014-04-01)

Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection.
by: Day, C, et al.
Published: (2007)

Identification and enhancement of HLA-A2.1-restricted CTL epitopes in a new human cancer antigen-POTE.
by: Yi-Hsiang Huang, et al.
Published: (2013-01-01)

Rare HLA drive additional HIV evolution compared to more frequent alleles.
by: Rousseau, C, et al.
Published: (2009)

Identification of class I HLA T cell control epitopes for West Nile virus.
by: Saghar Kaabinejadian, et al.
Published: (2013-01-01)

CTL epitope escape and reversion in acute HCV infection.
by: Timm, J, et al.
Published: (2004)

P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection
by: Bansal, A, et al.
Published: (2009)

P16-04. Cryptic CTL epitopes derived from antisense transcription are frequently recognized in HIV-1 infection
by: Goulder P, et al.
Published: (2009-10-01)

Revisiting the Influence of HLA-type, Frequency, HLA-supertype and Homozygosity on the Immune Control of HIV
by: Leslie, A, et al.
Published: (2008)

Definition of a New HLA B*52-Restricted Rev CTL Epitope Targeted by an HIV-1-Infected Controller
by: Boutaina El Kenz, et al.
Published: (2023-02-01)

Connecting MHC-I-binding motifs with HLA alleles via deep learning
by: Ko-Han Lee, et al.
Published: (2021-10-01)

CTL escape - Progress in identifying therapeutic avenues to control HIV viraemia
by: Goulder, P
Published: (2000)

HIV and SIV CTL escape: implications for vaccine design.
by: Goulder, P, et al.
Published: (2004)