Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients.
Major histocompatibility complex class I-related chain A (MICA) molecules are frequently expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D. In contrast, soluble MICA (sMICA) mo...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797064097606402048 |
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| author | Rebmann, V Schütt, P Brandhorst, D Opalka, B Moritz, T Nowrousian, MR Grosse-Wilde, H |
| author_facet | Rebmann, V Schütt, P Brandhorst, D Opalka, B Moritz, T Nowrousian, MR Grosse-Wilde, H |
| author_sort | Rebmann, V |
| collection | OXFORD |
| description | Major histocompatibility complex class I-related chain A (MICA) molecules are frequently expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D. In contrast, soluble MICA (sMICA) molecules impair the functions of NKG2D(+) T and NK cells, which may facilitate tumor cell escape from immunosurveillance. Here, we analyzed the clinical relevance of sMICA in 97 MM patients. sMICA (mean+/-SEM pg/ml) was significantly increased (p<0.0001) in patients (429+/-20) compared to controls (230+/-20; N=43). Serial determination showed a strong correlation between increments of sMICA and paraprotein levels (r=0.543, p<0.0001, N=49). sMICA levels >305 pg/ml are associated with a poor overall (p=0.004) and progression-free survival (p=0.002). Multivariate analysis revealed sMICA as an independent predictive factor for overall (p=0.007) and progression-free survival (p=0.002). Thus, our results suggest sMICA as a potent prognostic marker in MM, which may be useful to identify risk patients. |
| first_indexed | 2024-03-06T21:09:21Z |
| format | Journal article |
| id | oxford-uuid:3d9a9d10-15bd-48b1-b36a-5a5c485b7f3b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:09:21Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:3d9a9d10-15bd-48b1-b36a-5a5c485b7f3b2022-03-26T14:20:27ZSoluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3d9a9d10-15bd-48b1-b36a-5a5c485b7f3bEnglishSymplectic Elements at Oxford2007Rebmann, VSchütt, PBrandhorst, DOpalka, BMoritz, TNowrousian, MRGrosse-Wilde, HMajor histocompatibility complex class I-related chain A (MICA) molecules are frequently expressed in lymphoproliferative malignancies including multiple myeloma (MM). MICA activates NK cells and co-stimulates T cells by interaction with its immunoreceptor NKG2D. In contrast, soluble MICA (sMICA) molecules impair the functions of NKG2D(+) T and NK cells, which may facilitate tumor cell escape from immunosurveillance. Here, we analyzed the clinical relevance of sMICA in 97 MM patients. sMICA (mean+/-SEM pg/ml) was significantly increased (p<0.0001) in patients (429+/-20) compared to controls (230+/-20; N=43). Serial determination showed a strong correlation between increments of sMICA and paraprotein levels (r=0.543, p<0.0001, N=49). sMICA levels >305 pg/ml are associated with a poor overall (p=0.004) and progression-free survival (p=0.002). Multivariate analysis revealed sMICA as an independent predictive factor for overall (p=0.007) and progression-free survival (p=0.002). Thus, our results suggest sMICA as a potent prognostic marker in MM, which may be useful to identify risk patients. |
| spellingShingle | Rebmann, V Schütt, P Brandhorst, D Opalka, B Moritz, T Nowrousian, MR Grosse-Wilde, H Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title | Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title_full | Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title_fullStr | Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title_full_unstemmed | Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title_short | Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. |
| title_sort | soluble mica as an independent prognostic factor for the overall survival and progression free survival of multiple myeloma patients |
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