Oral rapamycin reduces tumour burden and vascularization in Lkb1(+/-) mice.
Patients with Peutz-Jeghers syndrome (PJS) are affected by hamartomatous intestinal polyposis and increased risk of cancers in multiple organs caused by germline mutations in the tumour suppressor gene LKB1. Murine models that recapitulate aspects of PJS have been created. Here we examine the therap...
Main Authors: | Robinson, J, Lai, C, Martin, A, Nye, E, Tomlinson, I, Silver, A |
---|---|
Format: | Journal article |
Language: | English |
Published: |
2009
|
Similar Items
-
Rapamycin rejuvenates oral health in aging mice
by: Jonathan Y An, et al.
Published: (2020-04-01) -
In situ analysis of LKB1/STK11 mRNA expression in human normal tissues and tumours.
by: Rowan, A, et al.
Published: (2000) -
LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome.
by: Volikos, E, et al.
Published: (2006) -
Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours.
by: Wang, Z, et al.
Published: (1999) -
Membrane-binding and activation of LKB1 by phosphatidic acid is essential for development and tumour suppression
by: Giada Dogliotti, et al.
Published: (2017-06-01)