Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

CCN2, a secreted profibrotic protein, is highly expressed in diabetic nephropathy (DN) and implicated in its pathogenesis; however, the actions of CCN2 in DN remain elusive. We previously demonstrated that CCN2 triggers signaling via tropomyosin receptor kinase A (TrkA). Trace expression of TrkA is...

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Detalhes bibliográficos
Principais autores:	Fragiadaki, M, Hill, N, Hewitt, R, Bou-Gharios, G, Cook, T, Tam, F, Domin, J, Mason, R
Formato:	Journal article
Idioma:	English
Publicado em:	2012

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