Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

CCN2, a secreted profibrotic protein, is highly expressed in diabetic nephropathy (DN) and implicated in its pathogenesis; however, the actions of CCN2 in DN remain elusive. We previously demonstrated that CCN2 triggers signaling via tropomyosin receptor kinase A (TrkA). Trace expression of TrkA is...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Fragiadaki, M, Hill, N, Hewitt, R, Bou-Gharios, G, Cook, T, Tam, F, Domin, J, Mason, R
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2012

Những quyển sách tương tự

Identification and structure of the nerve growth factor binding site on TrkA.
Bằng: Robertson, A, et al.
Được phát hành: (2001)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Bằng: Ashley J. Mason, et al.
Được phát hành: (2023-03-01)

NGF causes TrkA to specifically attract microtubules to lipid rafts.
Bằng: Shona Pryor, et al.
Được phát hành: (2012-01-01)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Bằng: Laura Calvo-Enrique, et al.
Được phát hành: (2023-09-01)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.
Bằng: Sylvia Josephy-Hernandez, et al.
Được phát hành: (2019-01-01)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
Bằng: Mengchen Ye, et al.
Được phát hành: (2018-01-01)

Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain
Bằng: Ritabrata Banerjee, et al.
Được phát hành: (2013-10-01)

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
Bằng: Hanzhi Zhang, et al.
Được phát hành: (2020-01-01)

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
Bằng: Damir Omerbašić, et al.
Được phát hành: (2016-10-01)

NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice
Bằng: Tomlinson, R, et al.
Được phát hành: (2017)

Crystal structure of a two-subunit TrkA octameric gating ring assembly.
Bằng: Marc C Deller, et al.
Được phát hành: (2015-01-01)

Early life stress disrupts intestinal homeostasis via NGF-TrkA signaling
Bằng: Hoi Leong Xavier Wong, et al.
Được phát hành: (2019-04-01)

Effect of Synthetic Cell-Penetrating Peptides on TrkA Activity in PC12 Cells
Bằng: Munetaka Hirose, et al.
Được phát hành: (2008-01-01)

NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone
Bằng: Tomlinson, R, et al.
Được phát hành: (2016)

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
Bằng: Tomlinson, R, et al.
Được phát hành: (2016)

A Study of Alternative TrkA Splicing Identifies TrkAIII as a Novel Potentially Targetable Participant in PitNET Progression
Bằng: Maddalena Sbaffone, et al.
Được phát hành: (2024-03-01)

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
Bằng: Daniele Narducci, et al.
Được phát hành: (2023-09-01)

TTF1 suppresses neuroblastoma growth and induces neuroblastoma differentiation by targeting TrkA and the miR-204/TrkB axis
Bằng: Tianyou Yang, et al.
Được phát hành: (2022-07-01)

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
Bằng: Holden, P, et al.
Được phát hành: (1997)

Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons.
Bằng: Bennett, D, et al.
Được phát hành: (1996)

Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish
Bằng: Pietro Cacialli
Được phát hành: (2022-05-01)

The Receptor Tyrosine Kinase TrkA Is Increased and Targetable in HER2-Positive Breast Cancer
Bằng: Nathan Griffin, et al.
Được phát hành: (2020-09-01)

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma
Bằng: Wenyu Shi, et al.
Được phát hành: (2017-09-01)

Cytoplasmic TrkA Expression as a Screen for Detecting NTRK1 Fusions in Colorectal Cancer
Bằng: Yuri Choi, et al.
Được phát hành: (2018-06-01)

TrkA serves as a virulence modulator in Porphyromonas gingivalis by maintaining heme acquisition and pathogenesis
Bằng: Renjie Zou, et al.
Được phát hành: (2022-11-01)

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts
Bằng: Mei-Ge Zheng, et al.
Được phát hành: (2019-01-01)

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
Bằng: Ryan E. Tomlinson, et al.
Được phát hành: (2016-09-01)

TrkA-cholinergic signaling modulates fear encoding and extinction learning in PTSD-like behavior
Bằng: Sudhirkumar Yanpallewar, et al.
Được phát hành: (2022-03-01)

72. The Role of TrkA And P75NTR NGF Receptors in Corneal Wound Healing
Bằng: Kiana Tajdaran, MD, MASc, et al.
Được phát hành: (2022-06-01)

Sprouty4 is an endogenous negative modulator of TrkA signaling and neuronal differentiation induced by NGF.
Bằng: Fernando C Alsina, et al.
Được phát hành: (2012-01-01)

IMMUNOHISTOCHEMICAL EXPRESSION OF NGF/TrkA AND BDNF/TrkB IN TUMOR PARIENCHYMA AND PERIPROSTATIC ADIPOSE TISSUE, DEPENDING ON THE PATHOANATOMIC STAGE OF PROSTATE CANCER
Bằng: Nikolay Evtimov
Được phát hành: (2024-02-01)

Hyperglycemia induced damage to mitochondrial respiration in renal mesangial and tubular cells: Implications for diabetic nephropathy
Bằng: Anna Czajka, et al.
Được phát hành: (2016-12-01)

TrkA promotes MDM2-mediated AGPS ubiquitination and degradation to trigger prostate cancer progression
Bằng: Yu Zhang, et al.
Được phát hành: (2024-01-01)

A Synthetic Cell-Penetrating Peptide Antagonizing TrkA Function Suppresses Neuropathic Pain in Mice
Bằng: Wei-Ying Ma, et al.
Được phát hành: (2010-01-01)

Exploring Morphine-Triggered PKC-Targets and Their Interaction with Signaling Pathways Leading to Pain via TrkA
Bằng: Darlene A. Pena, et al.
Được phát hành: (2018-10-01)

Diterpene Ginkgolides Exert an Antidepressant Effect Through the NT3-TrkA and Ras-MAPK Pathways
Bằng: Wang T, et al.
Được phát hành: (2020-03-01)

Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism
Bằng: Alexes C. Daquinag, et al.
Được phát hành: (2022-09-01)

Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA
Bằng: Simon Desiderio, et al.
Được phát hành: (2019-03-01)

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
Bằng: Shu Zhao, et al.
Được phát hành: (2020-11-01)

Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat
Bằng: N. Mirabella, et al.
Được phát hành: (2009-12-01)