Parameters for reliable results in genetic association studies in common disease.
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of th...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2002
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| _version_ | 1826268435805372416 |
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| author | Dahlman, I Eaves, I Kosoy, R Morrison, V Heward, J Gough, S Allahabadia, A Franklyn, J Tuomilehto, J Tuomilehto-Wolf, E Cucca, F Guja, C Ionescu-Tirgoviste, C Stevens, H Carr, P Nutland, S McKinney, P Shield, J Wang, W Cordell, H Walker, N Todd, J Concannon, P |
| author_facet | Dahlman, I Eaves, I Kosoy, R Morrison, V Heward, J Gough, S Allahabadia, A Franklyn, J Tuomilehto, J Tuomilehto-Wolf, E Cucca, F Guja, C Ionescu-Tirgoviste, C Stevens, H Carr, P Nutland, S McKinney, P Shield, J Wang, W Cordell, H Walker, N Todd, J Concannon, P |
| author_sort | Dahlman, I |
| collection | OXFORD |
| description | It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable. |
| first_indexed | 2024-03-06T21:09:38Z |
| format | Journal article |
| id | oxford-uuid:3db0c332-3faa-4d39-ba64-cd7b9959d641 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:09:38Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:3db0c332-3faa-4d39-ba64-cd7b9959d6412022-03-26T14:20:57ZParameters for reliable results in genetic association studies in common disease.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3db0c332-3faa-4d39-ba64-cd7b9959d641EnglishSymplectic Elements at Oxford2002Dahlman, IEaves, IKosoy, RMorrison, VHeward, JGough, SAllahabadia, AFranklyn, JTuomilehto, JTuomilehto-Wolf, ECucca, FGuja, CIonescu-Tirgoviste, CStevens, HCarr, PNutland, SMcKinney, PShield, JWang, WCordell, HWalker, NTodd, JConcannon, PIt is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable. |
| spellingShingle | Dahlman, I Eaves, I Kosoy, R Morrison, V Heward, J Gough, S Allahabadia, A Franklyn, J Tuomilehto, J Tuomilehto-Wolf, E Cucca, F Guja, C Ionescu-Tirgoviste, C Stevens, H Carr, P Nutland, S McKinney, P Shield, J Wang, W Cordell, H Walker, N Todd, J Concannon, P Parameters for reliable results in genetic association studies in common disease. |
| title | Parameters for reliable results in genetic association studies in common disease. |
| title_full | Parameters for reliable results in genetic association studies in common disease. |
| title_fullStr | Parameters for reliable results in genetic association studies in common disease. |
| title_full_unstemmed | Parameters for reliable results in genetic association studies in common disease. |
| title_short | Parameters for reliable results in genetic association studies in common disease. |
| title_sort | parameters for reliable results in genetic association studies in common disease |
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