Mechanisms and evolutionary patterns of mammalian and avian dosage compensation

Mechanisms and evolutionary patterns of mammalian and avian dosage compensation

As a result of sex chromosome differentiation from ancestral autosomes, male mammalian cells only contain one X chromosome. It has long been hypothesized that X-linked gene expression levels have become doubled in males to restore the original transcriptional output, and that the resulting X overexp...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Julien, P, Brawand, D, Soumillon, M, Necsulea, A, Liechti, A, Schütz, F, Daish, T, Grützner, F, Kaessmann, H
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	Public Library of Science 2012

Eitemau Tebyg

Mechanisms and evolutionary patterns of mammalian and avian dosage compensation.
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Transcription dosage compensation does not occur in Down syndrome
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The Drosophila over compensating males gene genetically inhibits dosage compensation in males.
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Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators
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Evolutionary versatility of the avian neck
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DOSAGE COMPENSATION: REGULATION OF SEX CHROMOSOME GENE EXPRESSION
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A general lack of compensation for gene dosage in yeast
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Dosage Compensation and Gene Expression of the X Chromosome in Sheep
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