Studies towards a stereocontrolled synthesis of the tricarboxylate core of the zaragozic acids-squalestatins by a cycloaddition-rearrangement strategy
Reaction of diazoketodiester 11 with methyl glyoxylate in toluene in the presence of catalytic rhodium(II) acetate gives predominantly the 6,8- dioxabicyclo[3.2.1]octane 13. Acid-catalysed rearrangement of the corresponding alcohol 14 favours at equilibrium the 2,8- dioxabicyclo[3.2.1]octane skeleto...
| Principais autores: | , |
|---|---|
| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
2000
|