The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?
Recent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with...
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1826268470573006848 |
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| author | Watt, S Forde, S |
| author_facet | Watt, S Forde, S |
| author_sort | Watt, S |
| collection | OXFORD |
| description | Recent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with a higher proportion of repopulating cells, but also enhance CD34(+) cell mobilization when used in combination with G-CSF. Here, we review the importance of CXCR4 and its ligand CXCL12 in haemopoiesis, and the potential roles of CXCR4 antagonists in the clinical HSC transplant setting. |
| first_indexed | 2024-03-06T21:10:10Z |
| format | Journal article |
| id | oxford-uuid:3ddfd5e1-a188-4bdb-918a-b359c5d017f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:10:10Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:3ddfd5e1-a188-4bdb-918a-b359c5d017f12022-03-26T14:22:03ZThe central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders?Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ddfd5e1-a188-4bdb-918a-b359c5d017f1EnglishSymplectic Elements at Oxford2008Watt, SForde, SRecent clinical trials have used CXCR4 antagonists for the rapid mobilization of CD34(+) haemopoietic stem/progenitor cells (HSC/HPC) from the bone marrow to the blood in patients refractory to granulocyte-colony-stimulating factor (G-CSF). These antagonists not only mobilize non-cycling cells with a higher proportion of repopulating cells, but also enhance CD34(+) cell mobilization when used in combination with G-CSF. Here, we review the importance of CXCR4 and its ligand CXCL12 in haemopoiesis, and the potential roles of CXCR4 antagonists in the clinical HSC transplant setting. |
| spellingShingle | Watt, S Forde, S The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title | The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title_full | The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title_fullStr | The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title_full_unstemmed | The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title_short | The central role of the chemokine receptor, CXCR4, in haemopoietic stem cell transplantation: will CXCR4 antagonists contribute to the treatment of blood disorders? |
| title_sort | central role of the chemokine receptor cxcr4 in haemopoietic stem cell transplantation will cxcr4 antagonists contribute to the treatment of blood disorders |
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