The indirect health effects of malaria estimated from health advantages of the sickle cell trait
Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (Hb...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Nature Research
2019
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| _version_ | 1797064157343776768 |
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| author | Uyoga, S Macharia, A Ndila, C Nyutu, G Shebe, M Awuondo, K Mturi, N Peshu, N Tsofa, B Scott, J Maitland, K Williams, T |
| author_facet | Uyoga, S Macharia, A Ndila, C Nyutu, G Shebe, M Awuondo, K Mturi, N Peshu, N Tsofa, B Scott, J Maitland, K Williams, T |
| author_sort | Uyoga, S |
| collection | OXFORD |
| description | Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000-2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22-0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67-0.93), bacteraemia (aOR 0.69; 0.54-0.88) and severe malnutrition (aOR 0.67; 0.55-0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions. |
| first_indexed | 2024-03-06T21:10:14Z |
| format | Journal article |
| id | oxford-uuid:3de3fc0a-205b-40dd-8c74-ae53e391e0d5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:10:14Z |
| publishDate | 2019 |
| publisher | Nature Research |
| record_format | dspace |
| spelling | oxford-uuid:3de3fc0a-205b-40dd-8c74-ae53e391e0d52022-03-26T14:22:14ZThe indirect health effects of malaria estimated from health advantages of the sickle cell traitJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3de3fc0a-205b-40dd-8c74-ae53e391e0d5EnglishSymplectic Elements at OxfordNature Research2019Uyoga, SMacharia, ANdila, CNyutu, GShebe, MAwuondo, KMturi, NPeshu, NTsofa, BScott, JMaitland, KWilliams, TMost estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000-2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22-0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67-0.93), bacteraemia (aOR 0.69; 0.54-0.88) and severe malnutrition (aOR 0.67; 0.55-0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions. |
| spellingShingle | Uyoga, S Macharia, A Ndila, C Nyutu, G Shebe, M Awuondo, K Mturi, N Peshu, N Tsofa, B Scott, J Maitland, K Williams, T The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title_full | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title_fullStr | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title_full_unstemmed | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title_short | The indirect health effects of malaria estimated from health advantages of the sickle cell trait |
| title_sort | indirect health effects of malaria estimated from health advantages of the sickle cell trait |
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