Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4+ decline
HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections initiated by a single genetic variant. Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4+ 4 T cell decline may be elevated, but these findings remain inconsi...
Main Authors: | Baxter, J, Villabona-Arenas, J, Thompson, RN, Hue, S, Regoes, R, Kouyos, R, Gunthard, H, Albert, J, Brown, AL, Atkins, K |
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Format: | Journal article |
Language: | English |
Published: |
Royal Society
2024
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