Reconciling founder variant multiplicity of HIV-1 infection with the rate of CD4+ decline
HIV-1 transmission precipitates a stringent genetic bottleneck, with 75% of new infections initiated by a single genetic variant. Where multiple variants initiate infection, recipient set point viral load (SpVL) and the rate of CD4+ 4 T cell decline may be elevated, but these findings remain inconsi...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Royal Society
2024
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