An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

An association analysis of the HLA gene region in latent autoimmune diabetes in adults.

AIMS/HYPOTHESIS: Pathophysiological similarities between latent autoimmune diabetes in adults (LADA) and type 1 diabetes indicate an overlap in genetic susceptibility. HLA-DRB1 and HLA-DQB1 are major susceptibility genes for type 1 diabetes but studies of these genes in LADA have been limited. Our...

Bibliografiset tiedot
Päätekijät:	Desai, M, Zeggini, E, Horton, V, Owen, K, Hattersley, A, Levy, J, Walker, M, Gillespie, K, Bingley, P, Hitman, G, Holman, R, McCarthy, M, Clark, A
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2007

Samankaltaisia teoksia

The variable number of tandem repeats upstream of the insulin gene is a susceptibility locus for latent autoimmune diabetes in adults.
Tekijä: Desai, M, et al.
Julkaistu: (2006)

Susceptibility for latent autoimmune diabetes in adults (LADA) is determined by variation at the 1DDM2 (insulin-gene) locus in white Caucasian patients from UK repositories
Tekijä: Desai, M, et al.
Julkaistu: (2005)

Susceptibility effects of variation at the IDDM2 (Insulin-gene) locus in latent autoimmune diabetes in adults (LADA).
Tekijä: Desai, M, et al.
Julkaistu: (2003)

Relationship of autoantibodies to glutamic acid decarboxylase (GADA) to deterioration of glycamic control assessed by therapy progression in latent autoimmune diabetes in adults (LADA) in the UKPDS
Tekijä: Clark, A, et al.
Julkaistu: (2005)

GAD65 autoantibody titres at diagnosis in Latent Autoimmune Diabetes in Adults (LADA) differ from Type 1 diabetes (T1D) and together with epitope specificity predict insulin requirement
Tekijä: Desai, M, et al.
Julkaistu: (2004)

GAD autoantibodies and epitope reactivities persist after diagnosis in latent autoimmune diabetes in adults but do not predict disease progression: UKPDS 77.
Tekijä: Desai, M, et al.
Julkaistu: (2007)

Common variation in the LMNA gene increases susceptibility to type 2 diabetes
Tekijä: Owen, K, et al.
Julkaistu: (2006)

Variation at the insulin VNTR locus but not the CTLA-4 locus is associated with age of onset and need for insulin therapy in latent autoimmune diabetes in adults (LADA)
Tekijä: Horton, V, et al.
Julkaistu: (2001)

Examining the relationships between the Pro12Ala variant in PPARG and Type 2 diabetes-related traits in UK samples.
Tekijä: Zeggini, E, et al.
Julkaistu: (2005)

TCF7L2: the biggest story in diabetes genetics since HLA?
Tekijä: Zeggini, E, et al.
Julkaistu: (2007)

Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Large-scale studies of the association between variation at the TNF/LTA locus and susceptibility to type 2 diabetes.
Tekijä: Zeggini, E, et al.
Julkaistu: (2005)

Role of the D76N polymorphism of insulin promoter factor-1 in predisposing to Type 2 diabetes.
Tekijä: Owen, K, et al.
Julkaistu: (2004)

Significant linkage of BMI to chromosome 10p in the U.K. population and evaluation of GAD2 as a positional candidate.
Tekijä: Groves, C, et al.
Julkaistu: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Combining information from common type 2 diabetes risk polymorphisms improves disease prediction.
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Large-scale association studies of candidate genes and their interactions in Type 2 diabetes
Tekijä: Zeggini, E, et al.
Julkaistu: (2004)

Analysis of the contribution to type 2 diabetes susceptibility of sequence variation in the gene encoding stearoyl-CoA desaturase, a key regulator of lipid and carbohydrate metabolism.
Tekijä: Liew, C, et al.
Julkaistu: (2004)

A large-scale association analysis of common variation of the HNF1alpha gene with type 2 diabetes in the U.K. Caucasian population.
Tekijä: Weedon, M, et al.
Julkaistu: (2005)

Insulin VNTR and HLA DRB1/DQB1 LOCI affect age of presentation of autoimmune diabetes in adults
Tekijä: Horton, V, et al.
Julkaistu: (1998)

GAD antibodies in probands and their relatives in a cohort clinically selected for Type 2 diabetes.
Tekijä: Castleden, H, et al.
Julkaistu: (2006)

An evaluation of HapMap sample size and tagging SNP performance in large-scale empirical and simulated data sets.
Tekijä: Zeggini, E, et al.
Julkaistu: (2005)

Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
Tekijä: Groves, C, et al.
Julkaistu: (2003)

Heritability estimates for beta cell function and features of the insulin resistance syndrome in UK families with an increased susceptibility to type 2 diabetes.
Tekijä: Mills, G, et al.
Julkaistu: (2004)

Genetic and immunological characterisation of patients with latent autoimmune diabetes in adults (LADA)
Tekijä: Desai, M, et al.
Julkaistu: (2005)

Sequencing PDX1 (insulin promoter factor 1) in 1788 UK individuals found 5% had a low frequency coding variant, but these variants are not associated with Type 2 diabetes.
Tekijä: Edghill, E, et al.
Julkaistu: (2011)

Association analysis of 6,736 U.K. subjects provides replication and confirms TCF7L2 as a type 2 diabetes susceptibility gene with a substantial effect on individual risk.
Tekijä: Groves, C, et al.
Julkaistu: (2006)

Assessment of the role of common genetic variation in the transient neonatal diabetes mellitus (TNDM) region in type 2 diabetes: a comparative genomic and tagging single nucleotide polymorphism approach.
Tekijä: Gloyn, A, et al.
Julkaistu: (2006)

Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
Tekijä: Frayling, T, et al.
Julkaistu: (2003)

No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians.
Tekijä: Weedon, M, et al.
Julkaistu: (2006)

Reduced beta cell function in offspring of mothers with young-onset type 2 diabetes.
Tekijä: Singh, R, et al.
Julkaistu: (2006)

Reduced beta cell function in offspring of mothers with young onset type 2 diabetes
Tekijä: Singh, R, et al.
Julkaistu: (2005)

Large scale case-control and family-based analyses of TCF7L2 variants in > 6000 UK subjects demonstrates an almost two-fold difference in relative risk between homozygote classes
Tekijä: Groves, C, et al.
Julkaistu: (2006)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
Tekijä: Gloyn, A, et al.
Julkaistu: (2003)

Large-scale association studies of variants in genes encoding the pancreatic beta-cell K-ATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
Tekijä: Gloyn, A, et al.
Julkaistu: (2003)

Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
Tekijä: Weedon, M, et al.
Julkaistu: (2004)

Functional variation in VEGF is not associated with type 2 diabetes in a United Kingdom Caucasian population.
Tekijä: Freathy, R, et al.
Julkaistu: (2006)

Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
Tekijä: Huxtable, S, et al.
Julkaistu: (2000)

Interrogating type 2 diabetes genome-wide association data using a biological pathway-based approach.
Tekijä: Perry, JR, et al.
Julkaistu: (2009)

Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
Tekijä: Wiltshire, S, et al.
Julkaistu: (2004)