Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

Restoring p53 function in human melanoma cells by inhibiting MDM2 and cyclin B1/CDK1-phosphorylated nuclear iASPP.

Nearly 90% of human melanomas contain inactivated wild-type p53, the underlying mechanisms for which are not fully understood. Here, we identify that cyclin B1/CDK1-phosphorylates iASPP, which leads to the inhibition of iASPP dimerization, promotion of iASPP monomer nuclear entry, and exposure of it...

Full description

Bibliographic Details
Main Authors: Lu, M, Breyssens, H, Salter, V, Zhong, S, Hu, Y, Baer, C, Ratnayaka, I, Sullivan, A, Brown, N, Endicott, J, Knapp, S, Kessler, B, Middleton, MR, Siebold, C, Jones, E, Sviderskaya, E, Cebon, J, John, T, Caballero, O, Goding, C, Lu, X
Format: Journal article
Language:English
Published: 2013

Similar Items

Similar Items