Targeting the Mycobacterium tuberculosis transpeptidase LdtMt2 with cysteine-reactive inhibitors including ebselen
The L,D-transpeptidases (Ldts) are promising antibiotic targets for treating tuberculosis. We report screening of cysteine-reactive inhibitors against LdtMt2 from Mycobacterium tuberculosis. Structural studies on LdtMt2 with potent inhibitor ebselen reveal opening of the benzisoselenazolone ring by...
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Bibliographic Details
| Main Authors: |
De Munnik, M,
Lohans, CT,
Lang, PA,
Langley, G,
Malla, TR,
Tumber, A,
Schofield, C,
Brem, J |
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| Format: | Journal article
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| Published: |
Royal Society of Chemistry
2019
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