Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.
Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolu...
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| Hlavní autoři: |
Ghansah, A,
Rockett, K,
Clark, T,
Wilson, MD,
Koram, K,
Oduro, A,
Amenga-Etego, L,
Anyorigiya, T,
Hodgson, A,
Milligan, P,
Rogers, W,
Kwiatkowski, D |
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| Médium: | Journal article
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| Jazyk: | English |
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| Vydáno: |
2012
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