Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.
Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolu...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2012
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| _version_ | 1826268527252733952 |
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| author | Ghansah, A Rockett, K Clark, T Wilson, MD Koram, K Oduro, A Amenga-Etego, L Anyorigiya, T Hodgson, A Milligan, P Rogers, W Kwiatkowski, D |
| author_facet | Ghansah, A Rockett, K Clark, T Wilson, MD Koram, K Oduro, A Amenga-Etego, L Anyorigiya, T Hodgson, A Milligan, P Rogers, W Kwiatkowski, D |
| author_sort | Ghansah, A |
| collection | OXFORD |
| description | Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana. |
| first_indexed | 2024-03-06T21:11:04Z |
| format | Journal article |
| id | oxford-uuid:3e299bcd-3ce8-4ef1-ae47-daf9c4323afd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:11:04Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:3e299bcd-3ce8-4ef1-ae47-daf9c4323afd2022-03-26T14:24:00ZHaplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3e299bcd-3ce8-4ef1-ae47-daf9c4323afdEnglishSymplectic Elements at Oxford2012Ghansah, ARockett, KClark, TWilson, MDKoram, KOduro, AAmenga-Etego, LAnyorigiya, THodgson, AMilligan, PRogers, WKwiatkowski, DHaemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolutionary history of the malaria-protective alleles HbS and HbC in the Kassena-Nankana District (KND) of Ghana. |
| spellingShingle | Ghansah, A Rockett, K Clark, T Wilson, MD Koram, K Oduro, A Amenga-Etego, L Anyorigiya, T Hodgson, A Milligan, P Rogers, W Kwiatkowski, D Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title | Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title_full | Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title_fullStr | Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title_full_unstemmed | Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title_short | Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana. |
| title_sort | haplotype analyses of haemoglobin c and haemoglobin s and the dynamics of the evolutionary response to malaria in kassena nankana district of ghana |
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