Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.

Haplotype analyses of haemoglobin C and haemoglobin S and the dynamics of the evolutionary response to malaria in Kassena-Nankana District of Ghana.

Haemoglobin S (HbS) and C (HbC) are variants of the HBB gene which both protect against malaria. It is not clear, however, how these two alleles have evolved in the West African countries where they co-exist at high frequencies. Here we use haplotypic signatures of selection to investigate the evolu...

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Bibliografiske detaljer
Main Authors:	Ghansah, A, Rockett, K, Clark, T, Wilson, MD, Koram, K, Oduro, A, Amenga-Etego, L, Anyorigiya, T, Hodgson, A, Milligan, P, Rogers, W, Kwiatkowski, D
Format:	Journal article
Sprog:	English
Udgivet:	2012

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