Neuroscience of apathy and anhedonia: a transdiagnostic approach
Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The...
| Asıl Yazarlar: | , |
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| Materyal Türü: | Journal article |
| Baskı/Yayın Bilgisi: |
Springer Nature
2018
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| _version_ | 1826268546678652928 |
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| author | Husain, M Roiser, J |
| author_facet | Husain, M Roiser, J |
| author_sort | Husain, M |
| collection | OXFORD |
| description | Apathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions. |
| first_indexed | 2024-03-06T21:11:21Z |
| format | Journal article |
| id | oxford-uuid:3e481f87-0ede-47dd-bdd8-2db78dfd3694 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:11:21Z |
| publishDate | 2018 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:3e481f87-0ede-47dd-bdd8-2db78dfd36942022-03-26T14:24:32ZNeuroscience of apathy and anhedonia: a transdiagnostic approachJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3e481f87-0ede-47dd-bdd8-2db78dfd3694Symplectic Elements at OxfordSpringer Nature2018Husain, MRoiser, JApathy and anhedonia are common syndromes of motivation that are associated with a wide range of brain disorders and have no established therapies. Research using animal models suggests that a useful framework for understanding motivated behaviour lies in effort-based decision making for reward. The neurobiological mechanisms underpinning such decisions have now begun to be determined in individuals with apathy or anhedonia, providing an important foundation for developing new treatments. The findings suggest that there might be some shared mechanisms between both syndromes. A transdiagnostic approach that cuts across traditional disease boundaries provides a potentially useful means for understanding these conditions. |
| spellingShingle | Husain, M Roiser, J Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title | Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title_full | Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title_fullStr | Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title_full_unstemmed | Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title_short | Neuroscience of apathy and anhedonia: a transdiagnostic approach |
| title_sort | neuroscience of apathy and anhedonia a transdiagnostic approach |
| work_keys_str_mv | AT husainm neuroscienceofapathyandanhedoniaatransdiagnosticapproach AT roiserj neuroscienceofapathyandanhedoniaatransdiagnosticapproach |