Anticancer and immunosuppressive properties of bacterial prodiginines.
Bacterial prodiginines are a family of red-pigmented, tripyrrolic compounds that display numerous biological activities, including antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive and anticancer properties. Recently, significant progress has been made in understanding the bi...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2007
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| _version_ | 1797064235575934976 |
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| author | Williamson, N Fineran, P Gristwood, T Chawrai, SR Leeper, F Salmond, G |
| author_facet | Williamson, N Fineran, P Gristwood, T Chawrai, SR Leeper, F Salmond, G |
| author_sort | Williamson, N |
| collection | OXFORD |
| description | Bacterial prodiginines are a family of red-pigmented, tripyrrolic compounds that display numerous biological activities, including antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive and anticancer properties. Recently, significant progress has been made in understanding the biosynthesis and regulation of bacterial prodiginines. An understanding of the biosynthesis of prodiginines will allow engineering of bacterial strains capable of synthesizing novel prodiginines through rational design and mutasynthesis experiments. Bacterial prodiginines and synthetic derivatives are effective proapoptotic agents with multiple cellular targets, and they are active against numerous cancer cell lines, including multidrug-resistant cells, with little or no toxicity towards normal cell lines. A synthetic derivative, GX15-070 (Obatoclax), developed through structure-activity relationship studies of the pyrrolic ring A of GX15, is in multiple Phase I and II clinical trials in both single and dual-agent studies to treat different types of cancer. Therefore, prodiginines have real therapeutic potential in the clinic. |
| first_indexed | 2024-03-06T21:11:21Z |
| format | Journal article |
| id | oxford-uuid:3e48f7de-70bf-4db2-a669-2edf746e015f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:11:21Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:3e48f7de-70bf-4db2-a669-2edf746e015f2022-03-26T14:24:35ZAnticancer and immunosuppressive properties of bacterial prodiginines.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3e48f7de-70bf-4db2-a669-2edf746e015fEnglishSymplectic Elements at Oxford2007Williamson, NFineran, PGristwood, TChawrai, SRLeeper, FSalmond, GBacterial prodiginines are a family of red-pigmented, tripyrrolic compounds that display numerous biological activities, including antibacterial, antifungal, antiprotozoal, antimalarial, immunosuppressive and anticancer properties. Recently, significant progress has been made in understanding the biosynthesis and regulation of bacterial prodiginines. An understanding of the biosynthesis of prodiginines will allow engineering of bacterial strains capable of synthesizing novel prodiginines through rational design and mutasynthesis experiments. Bacterial prodiginines and synthetic derivatives are effective proapoptotic agents with multiple cellular targets, and they are active against numerous cancer cell lines, including multidrug-resistant cells, with little or no toxicity towards normal cell lines. A synthetic derivative, GX15-070 (Obatoclax), developed through structure-activity relationship studies of the pyrrolic ring A of GX15, is in multiple Phase I and II clinical trials in both single and dual-agent studies to treat different types of cancer. Therefore, prodiginines have real therapeutic potential in the clinic. |
| spellingShingle | Williamson, N Fineran, P Gristwood, T Chawrai, SR Leeper, F Salmond, G Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title | Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title_full | Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title_fullStr | Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title_full_unstemmed | Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title_short | Anticancer and immunosuppressive properties of bacterial prodiginines. |
| title_sort | anticancer and immunosuppressive properties of bacterial prodiginines |
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