Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

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Virus diversity and escape from immune responses are the biggest challenges to the development of an effective vaccine against HIV-1. We hypothesized that T-cell vaccines targeting the most conserved regions of the HIV-1 proteome, which are common to most variants and bear fitness costs when mutated...

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Bibliographic Details
Main Authors: Borthwick, N, Ahmed, T, Ondondo, B, Hayes, P, Rose, A, Ebrahimsa, U, Hayton, E, Black, A, Bridgeman, A, Rosario, M, Hill, A, Berrie, E, Moyle, S, Frahm, N, Cox, J, Colloca, S, Nicosia, A, Gilmour, J, McMichael, A, Dorrell, L, Hanke, T
Format: Journal article
Language:English
Published: 2014

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