Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.
Virus diversity and escape from immune responses are the biggest challenges to the development of an effective vaccine against HIV-1. We hypothesized that T-cell vaccines targeting the most conserved regions of the HIV-1 proteome, which are common to most variants and bear fitness costs when mutated...
Үндсэн зохиолчид: | Borthwick, N, Ahmed, T, Ondondo, B, Hayes, P, Rose, A, Ebrahimsa, U, Hayton, E, Black, A, Bridgeman, A, Rosario, M, Hill, A, Berrie, E, Moyle, S, Frahm, N, Cox, J, Colloca, S, Nicosia, A, Gilmour, J, McMichael, A, Dorrell, L, Hanke, T |
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Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
2014
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Ижил төстэй зүйлс
Ижил төстэй зүйлс
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Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1
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Recombinant DNA/MVA/ChAdV-63-elicited T cells specific for conserved regions of the HIV-1 proteome recognize HIV-1 infected cells and suppress HIV-1
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Immunogenicity of a universal HIV-1 vaccine vectored by DNA, MVA and CHADV-63 in a Phase I/IIA clinical trial
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The HIVconsv Vaccines Induce Polyfunctional and Highly Proliferative T Cells that Control In Vitro HIV Replication: HIV-CORE002 Phase-I Clinical Trial
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