Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

GW406381 (8), currently undergoing clinical evaluation for the treatment of inflammatory pain is a member of a novel series of 2,3-diaryl-pyrazolo[1,5-b]pyridazine based cyclooxygenase-2 (COX-2) inhibitors, which have been shown to be highly potent and selective. Several examples of the series, in a...

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Detalhes bibliográficos
Main Authors:	Beswick, P, Bingham, S, Bountra, C, Brown, T, Browning, K, Campbell, I, Chessell, I, Clayton, N, Collins, S, Corfield, J, Guntrip, S, Haslam, C, Lambeth, P, Lucas, F, Mathews, N, Murkit, G, Naylor, A, Pegg, N, Pickup, E, Player, H, Price, H, Stevens, A, Stratton, S, Wiseman, J
Formato:	Journal article
Idioma:	English
Publicado em:	2004

Identification of 2,3-diaryl-pyrazolo[1,5-b]pyridazines as potent and selective cyclooxygenase-2 inhibitors.

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