Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry. Cartilage explants were cultured in medium containing [35S]methionine/cysteine to radiolabel newly synthesized...

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Detalhes bibliográficos
Main Authors:	Hermansson, M, Sawaji, Y, Bolton, M, Alexander, S, Wallace, A, Begum, S, Wait, R, Saklatvala, J
Formato:	Journal article
Idioma:	English
Publicado em:	2004

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