Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry. Cartilage explants were cultured in medium containing [35S]methionine/cysteine to radiolabel newly synthesized...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Hermansson, M, Sawaji, Y, Bolton, M, Alexander, S, Wallace, A, Begum, S, Wait, R, Saklatvala, J
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	2004

Παρόμοια τεκμήρια

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
ανά: Alexander, S, κ.ά.
Έκδοση: (2007)

Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
ανά: Vincent, T, κ.ά.
Έκδοση: (2002)

Induction of interleukin-1 in articular cartilage by explantation and cutting.
ανά: Gruber, J, κ.ά.
Έκδοση: (2004)

Two-dimensional electrophoresis of proteins secreted from articular cartilage.
ανά: Hermansson, M, κ.ά.
Έκδοση: (2007)

Basic fibroblast growth factor (FGF) mediator of the immediate injury response in articular cartilage
ανά: Vincent, T, κ.ά.
Έκδοση: (2001)

BASIC FIBROBLAST GROWTH FACTOR (bFGF) MEDIATES THE IMMEDIATE INJURY RESPONSE IN ARTICULAR CARTILAGE
ανά: Vincent, T, κ.ά.
Έκδοση: (2002)

Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
ανά: Watt, F, κ.ά.
Έκδοση: (2008)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
ανά: Didangelos, A, κ.ά.
Έκδοση: (2009)

Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
ανά: Watt, F, κ.ά.
Έκδοση: (2009)

Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?
ανά: Vincent, T, κ.ά.
Έκδοση: (2006)

Activins and Inhibins in Cardiovascular Pathophysiology
ανά: Wenyi Tang, κ.ά.
Έκδοση: (2024-11-01)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
ανά: Sawaji, Y, κ.ά.
Έκδοση: (2009)

Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue
ανά: Sawaji, Y, κ.ά.
Έκδοση: (2009)

Changes in the reproductive function and developmental phenotypes in mice following intramuscular injection of an activin betaA-expressing plasmid
ανά: Mayo Kelly E, κ.ά.
Έκδοση: (2008-12-01)

INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB
ανά: Ismail, H, κ.ά.
Έκδοση: (2013)

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
ανά: Peng Li, κ.ά.
Έκδοση: (2024-01-01)

Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
ανά: Sawaji, Y, κ.ά.
Έκδοση: (2008)

FUNCTIONS OF THE mTOR SIGNALING PATHWAY IN NORMAL ARTICULAR CARTILAGE CHONDROCYTES AND IN OSTEOARTHRITIS
ανά: E. V. Chetina, κ.ά.
Έκδοση: (2016-12-01)

Wounding articular cartilage rapidly activates multiple signalling events in chondrocytes involving protein phosphorylation and polyubiquitination
ανά: Ismail, H, κ.ά.
Έκδοση: (2014)

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A
ανά: Yusuke Arino, κ.ά.
Έκδοση: (2025-02-01)

The effects of age and cell isolation on collagen II synthesis by articular chondrocytes: evidence for transcriptional and posttranscriptional regulation
ανά: Asopa, V, κ.ά.
Έκδοση: (2020)

Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes
ανά: Watt, F, κ.ά.
Έκδοση: (2006)

Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder
ανά: Weipu Mao, κ.ά.
Έκδοση: (2025-03-01)

The minor collagens in articular cartilage
ανά: Yunyun Luo, κ.ά.
Έκδοση: (2017-02-01)

Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination
ανά: Ismail, H, κ.ά.
Έκδοση: (2017)

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
ανά: Vincent, T, κ.ά.
Έκδοση: (2007)

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
ανά: Saklatvala, J
Έκδοση: (2007)

Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction.
ανά: Cheng Zhao, κ.ά.
Έκδοση: (2022-12-01)

Articular Cartilage Regeneration in Osteoarthritis
ανά: Livia Roseti, κ.ά.
Έκδοση: (2019-10-01)

Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome
ανά: Ping Shen, κ.ά.
Έκδοση: (2022-11-01)

The fate of implanted autologous chondrocytes in regenerated articular cartilage.
ανά: Min, B, κ.ά.
Έκδοση: (2007)

Articular cartilage collagen: an irreplaceable framework?
ανά: D R Eyre, κ.ά.
Έκδοση: (2006-11-01)

Articular cartilage collagen: an irreplaceable framework?
ανά: DR Eyre, κ.ά.
Έκδοση: (2006-11-01)

Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.
ανά: Vincent, T, κ.ά.
Έκδοση: (2004)

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus
ανά: N.B. Cruz-Cano, κ.ά.
Έκδοση: (2023-09-01)

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas
ανά: J. J. Staudacher, κ.ά.
Έκδοση: (2022-09-01)

The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation
ανά: Reichardt Holger M, κ.ά.
Έκδοση: (2008-05-01)

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
ανά: Hemanth Akkiraju, κ.ά.
Έκδοση: (2015-12-01)

NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis.
ανά: Midwood, K, κ.ά.
Έκδοση: (2001)

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.
ανά: Gardiner, MD, κ.ά.
Έκδοση: (2014)