Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

We show that proteomic analysis can be applied to study cartilage pathophysiology. Proteins secreted by articular cartilage were analyzed by two-dimensional SDS-PAGE and mass spectrometry. Cartilage explants were cultured in medium containing [35S]methionine/cysteine to radiolabel newly synthesized...

Bibliográfalaš dieđut
Váldodahkkit:	Hermansson, M, Sawaji, Y, Bolton, M, Alexander, S, Wallace, A, Begum, S, Wait, R, Saklatvala, J
Materiálatiipa:	Journal article
Giella:	English
Almmustuhtton:	2004

Geahča maid

Activin A is an anticatabolic autocrine cytokine in articular cartilage whose production is controlled by fibroblast growth factor 2 and NF-kappaB.
Dahkki: Alexander, S, et al.
Almmustuhtton: (2007)

Basic FGF mediates an immediate response of articular cartilage to mechanical injury.
Dahkki: Vincent, T, et al.
Almmustuhtton: (2002)

Induction of interleukin-1 in articular cartilage by explantation and cutting.
Dahkki: Gruber, J, et al.
Almmustuhtton: (2004)

Two-dimensional electrophoresis of proteins secreted from articular cartilage.
Dahkki: Hermansson, M, et al.
Almmustuhtton: (2007)

Basic fibroblast growth factor (FGF) mediator of the immediate injury response in articular cartilage
Dahkki: Vincent, T, et al.
Almmustuhtton: (2001)

BASIC FIBROBLAST GROWTH FACTOR (bFGF) MEDIATES THE IMMEDIATE INJURY RESPONSE IN ARTICULAR CARTILAGE
Dahkki: Vincent, T, et al.
Almmustuhtton: (2002)

Activin is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
Dahkki: Watt, F, et al.
Almmustuhtton: (2008)

Apolipoprotein A-1 is a novel inducer of aggrecan breakdown in cultured articular cartilage
Dahkki: Didangelos, A, et al.
Almmustuhtton: (2009)

Activin A is an anti-catabolic cytokine produced by injured cartilage via release of fibroblast growth factor-2 and activation of nuclear factor kappa B
Dahkki: Watt, F, et al.
Almmustuhtton: (2009)

Pericellular matrix of articular cartilage. A novel mechanotransduction mechanism in articular chondrocytes?
Dahkki: Vincent, T, et al.
Almmustuhtton: (2006)

Activins and Inhibins in Cardiovascular Pathophysiology
Dahkki: Wenyi Tang, et al.
Almmustuhtton: (2024-11-01)

Anti-catabolic effect of fibroblast growth factor-2 in human articular cartilage
Dahkki: Sawaji, Y, et al.
Almmustuhtton: (2009)

Dexamethasone inhibits aggrecanolysis in human articular cartilage but promotes it in porcine tissue
Dahkki: Sawaji, Y, et al.
Almmustuhtton: (2009)

Changes in the reproductive function and developmental phenotypes in mice following intramuscular injection of an activin betaA-expressing plasmid
Dahkki: Mayo Kelly E, et al.
Almmustuhtton: (2008-12-01)

INTERLEUKIN 1 INDUCES AGGRECAN DEGRADATION BY HUMAN ARTICULAR CHONDROCYTES THROUGH A TAK1/MKK4/JNK2 PATHWAY WITHOUT INVOLVEMENT OF NFKB
Dahkki: Ismail, H, et al.
Almmustuhtton: (2013)

Protective effects of ectoine on articular chondrocytes and cartilage in rats for treating osteoarthritis.
Dahkki: Peng Li, et al.
Almmustuhtton: (2024-01-01)

Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.
Dahkki: Sawaji, Y, et al.
Almmustuhtton: (2008)

FUNCTIONS OF THE mTOR SIGNALING PATHWAY IN NORMAL ARTICULAR CARTILAGE CHONDROCYTES AND IN OSTEOARTHRITIS
Dahkki: E. V. Chetina, et al.
Almmustuhtton: (2016-12-01)

Wounding articular cartilage rapidly activates multiple signalling events in chondrocytes involving protein phosphorylation and polyubiquitination
Dahkki: Ismail, H, et al.
Almmustuhtton: (2014)

Short-term overloading exercise attenuates articular chondrocyte features partly via synovium–cartilage interactions mediated by inhibin subunit beta A
Dahkki: Yusuke Arino, et al.
Almmustuhtton: (2025-02-01)

The effects of age and cell isolation on collagen II synthesis by articular chondrocytes: evidence for transcriptional and posttranscriptional regulation
Dahkki: Asopa, V, et al.
Almmustuhtton: (2020)

Sharp injury to articular cartilage activates JNK and NF kappa B and induces expression of inflammatory response genes
Dahkki: Watt, F, et al.
Almmustuhtton: (2006)

Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder
Dahkki: Weipu Mao, et al.
Almmustuhtton: (2025-03-01)

The minor collagens in articular cartilage
Dahkki: Yunyun Luo, et al.
Almmustuhtton: (2017-02-01)

Articular cartilage injury rapidly activates TAK1 in chondrocytes by inducing its phosphorylation and K63-polyubiquitination
Dahkki: Ismail, H, et al.
Almmustuhtton: (2017)

FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.
Dahkki: Vincent, T, et al.
Almmustuhtton: (2007)

Inflammatory signaling in cartilage: MAPK and NF-kappaB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis.
Dahkki: Saklatvala, J
Almmustuhtton: (2007)

Genetic analysis of activin/inhibin β subunits in zebrafish development and reproduction.
Dahkki: Cheng Zhao, et al.
Almmustuhtton: (2022-12-01)

Articular Cartilage Regeneration in Osteoarthritis
Dahkki: Livia Roseti, et al.
Almmustuhtton: (2019-10-01)

Optimization of chondrocyte isolation from human articular cartilage to preserve the chondrocyte transcriptome
Dahkki: Ping Shen, et al.
Almmustuhtton: (2022-11-01)

The fate of implanted autologous chondrocytes in regenerated articular cartilage.
Dahkki: Min, B, et al.
Almmustuhtton: (2007)

Articular cartilage collagen: an irreplaceable framework?
Dahkki: D R Eyre, et al.
Almmustuhtton: (2006-11-01)

Articular cartilage collagen: an irreplaceable framework?
Dahkki: DR Eyre, et al.
Almmustuhtton: (2006-11-01)

Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.
Dahkki: Vincent, T, et al.
Almmustuhtton: (2004)

Immunolocalization of activin and inhibin at different stages of follicular development in the lizard Sceloporus torquatus
Dahkki: N.B. Cruz-Cano, et al.
Almmustuhtton: (2023-09-01)

Prognostic impact of activin subunit inhibin beta A in gastric and esophageal adenocarcinomas
Dahkki: J. J. Staudacher, et al.
Almmustuhtton: (2022-09-01)

The glycoprotein-hormones activin A and inhibin A interfere with dendritic cell maturation
Dahkki: Reichardt Holger M, et al.
Almmustuhtton: (2008-05-01)

Role of Chondrocytes in Cartilage Formation, Progression of Osteoarthritis and Cartilage Regeneration
Dahkki: Hemanth Akkiraju, et al.
Almmustuhtton: (2015-12-01)

NG2/HMPG modulation of human articular chondrocyte adhesion to type VI collagen is lost in osteoarthritis.
Dahkki: Midwood, K, et al.
Almmustuhtton: (2001)

Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.
Dahkki: Gardiner, MD, et al.
Almmustuhtton: (2014)