Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.
In an open-label trial carried out on the northwest border of Thailand, 1596 patients with uncomplicated multidrug-resistant falciparum malaria were randomly assigned to receive atovaquone-proguanil, atovaquone-proguanil-artesunate, or artesunate-mefloquine and were followed up for 42 days. All 3 re...
| Hoofdauteurs: | , , , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
2002
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| _version_ | 1826268599856136192 |
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| author | van Vugt, M Leonardi, E Phaipun, L Slight, T Thway, K Mcgready, R Brockman, A Villegas, L Looareesuwan, S White, N Nosten, F |
| author_facet | van Vugt, M Leonardi, E Phaipun, L Slight, T Thway, K Mcgready, R Brockman, A Villegas, L Looareesuwan, S White, N Nosten, F |
| author_sort | van Vugt, M |
| collection | OXFORD |
| description | In an open-label trial carried out on the northwest border of Thailand, 1596 patients with uncomplicated multidrug-resistant falciparum malaria were randomly assigned to receive atovaquone-proguanil, atovaquone-proguanil-artesunate, or artesunate-mefloquine and were followed up for 42 days. All 3 regimens were highly effective and well tolerated. Fever duration and parasite clearance times were significantly shorter among patients who received artesunate (P<.001). Polymerase chain reaction genotyping confirmed that recrudescence occurred in 13 patients who received artesunate-mefloquine (2.4%), 5 who received atovaquone-proguanil-artesunate (0.9%), and 15 who received atovaquone-proguanil (2.8%). Adding artesunate to atovaquone-proguanil reduced the risk of failure 3-fold (95% confidence interval [CI], 1.1-8.2) and subsequent gametocyte carriage 21-fold (95% CI, 14-30). Gastrointestinal complaints in the first 48 h after initiation of treatment were more common among artesunate recipients, but after day 2, dizziness, sleep disturbance, nausea, vomiting, and anorexia were more common among mefloquine recipients (P< or =.014). Artesunate-atovaquone-proguanil is a highly effective and well-tolerated treatment for multidrug-resistant falciparum malaria. |
| first_indexed | 2024-03-06T21:12:10Z |
| format | Journal article |
| id | oxford-uuid:3e8d9df2-b39a-403c-a569-467a5200a549 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:12:10Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:3e8d9df2-b39a-403c-a569-467a5200a5492022-03-26T14:26:11ZTreatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3e8d9df2-b39a-403c-a569-467a5200a549EnglishSymplectic Elements at Oxford2002van Vugt, MLeonardi, EPhaipun, LSlight, TThway, KMcgready, RBrockman, AVillegas, LLooareesuwan, SWhite, NNosten, FIn an open-label trial carried out on the northwest border of Thailand, 1596 patients with uncomplicated multidrug-resistant falciparum malaria were randomly assigned to receive atovaquone-proguanil, atovaquone-proguanil-artesunate, or artesunate-mefloquine and were followed up for 42 days. All 3 regimens were highly effective and well tolerated. Fever duration and parasite clearance times were significantly shorter among patients who received artesunate (P<.001). Polymerase chain reaction genotyping confirmed that recrudescence occurred in 13 patients who received artesunate-mefloquine (2.4%), 5 who received atovaquone-proguanil-artesunate (0.9%), and 15 who received atovaquone-proguanil (2.8%). Adding artesunate to atovaquone-proguanil reduced the risk of failure 3-fold (95% confidence interval [CI], 1.1-8.2) and subsequent gametocyte carriage 21-fold (95% CI, 14-30). Gastrointestinal complaints in the first 48 h after initiation of treatment were more common among artesunate recipients, but after day 2, dizziness, sleep disturbance, nausea, vomiting, and anorexia were more common among mefloquine recipients (P< or =.014). Artesunate-atovaquone-proguanil is a highly effective and well-tolerated treatment for multidrug-resistant falciparum malaria. |
| spellingShingle | van Vugt, M Leonardi, E Phaipun, L Slight, T Thway, K Mcgready, R Brockman, A Villegas, L Looareesuwan, S White, N Nosten, F Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title | Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title_full | Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title_fullStr | Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title_full_unstemmed | Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title_short | Treatment of uncomplicated multidrug-resistant falciparum malaria with artesunate-atovaquone-proguanil. |
| title_sort | treatment of uncomplicated multidrug resistant falciparum malaria with artesunate atovaquone proguanil |
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