Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.

The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic fa...

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Main Author: Palace, J
Format: Journal article
Language:English
Published: 2009
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author Palace, J
author_facet Palace, J
author_sort Palace, J
collection OXFORD
description The cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identified to date, appear to play only a moderate role. One curious observation is that Leber's Hereditary Optic Neuropathy (LHON), a rare genetic syndrome, presents clinically overwhelmingly in males, but can be associated with an MS-like illness and when it does it occurs mainly in females. It is interesting to examine this further to assess if this could give us any clues as to the pathogenesis of MS.
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spelling oxford-uuid:3e92c85f-54b5-4ad7-9d99-dfcb4dda48d62022-03-26T14:26:19ZMultiple sclerosis associated with Leber's Hereditary Optic Neuropathy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3e92c85f-54b5-4ad7-9d99-dfcb4dda48d6EnglishSymplectic Elements at Oxford2009Palace, JThe cause of multiple sclerosis is unknown although it is recognised to involve an inflammatory process associated with demyelinating plaques and more widespread neurodegeneration. It appears to have become progressively more common in females which is further discussed in this issue, and genetic factors, as identified to date, appear to play only a moderate role. One curious observation is that Leber's Hereditary Optic Neuropathy (LHON), a rare genetic syndrome, presents clinically overwhelmingly in males, but can be associated with an MS-like illness and when it does it occurs mainly in females. It is interesting to examine this further to assess if this could give us any clues as to the pathogenesis of MS.
spellingShingle Palace, J
Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title_full Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title_fullStr Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title_full_unstemmed Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title_short Multiple sclerosis associated with Leber's Hereditary Optic Neuropathy.
title_sort multiple sclerosis associated with leber s hereditary optic neuropathy
work_keys_str_mv AT palacej multiplesclerosisassociatedwithlebershereditaryopticneuropathy