Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

Loss of viral fitness and cross-recognition by CD8+ T cells limit HCV escape from a protective HLA-B27-restricted human immune response.

There is an association between expression of the MHC class I molecule HLA-B27 and protection following human infection with either HIV or HCV. In both cases, protection has been linked to HLA-B27 presentation of a single immunodominant viral peptide epitope to CD8+ T cells. If HIV mutates the HLA-B...

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Détails bibliographiques
Auteurs principaux: Dazert, E, Neumann-Haefelin, C, Bressanelli, S, Fitzmaurice, K, Kort, J, Timm, J, McKiernan, S, Kelleher, D, Gruener, N, Tavis, J, Rosen, H, Shaw, J, Bowness, P, Blum, H, Klenerman, P, Bartenschlager, R, Thimme, R
Format: Journal article
Langue:English
Publié: 2009

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