Cerebral malaria.
Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogeneous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children. Recent studies have...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1797064332663586816 |
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| author | Newton, C Hien, T White, N |
| author_facet | Newton, C Hien, T White, N |
| author_sort | Newton, C |
| collection | OXFORD |
| description | Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogeneous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children. Recent studies have elucidated the molecular mechanisms of pathogenesis and raised possible interventions. Antimalarial drugs, however, remain the only intervention that unequivocally affects outcome, although increasing resistance to the established antimalarial drugs is of grave concern. Artemisinin derivatives have made an impact on treatment, but other drugs may be required. With appropriate antimalarial drugs, the prognosis of cerebral malaria often depends on the management of other complications-for example, renal failure and acidosis. Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments. |
| first_indexed | 2024-03-06T21:12:45Z |
| format | Journal article |
| id | oxford-uuid:3ebde190-ac3a-4117-80bd-7b5779d24d8a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:12:45Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:3ebde190-ac3a-4117-80bd-7b5779d24d8a2022-03-26T14:27:20ZCerebral malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ebde190-ac3a-4117-80bd-7b5779d24d8aEnglishSymplectic Elements at Oxford2000Newton, CHien, TWhite, NCerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogeneous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs between adults and children. Recent studies have elucidated the molecular mechanisms of pathogenesis and raised possible interventions. Antimalarial drugs, however, remain the only intervention that unequivocally affects outcome, although increasing resistance to the established antimalarial drugs is of grave concern. Artemisinin derivatives have made an impact on treatment, but other drugs may be required. With appropriate antimalarial drugs, the prognosis of cerebral malaria often depends on the management of other complications-for example, renal failure and acidosis. Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments. |
| spellingShingle | Newton, C Hien, T White, N Cerebral malaria. |
| title | Cerebral malaria. |
| title_full | Cerebral malaria. |
| title_fullStr | Cerebral malaria. |
| title_full_unstemmed | Cerebral malaria. |
| title_short | Cerebral malaria. |
| title_sort | cerebral malaria |
| work_keys_str_mv | AT newtonc cerebralmalaria AT hient cerebralmalaria AT whiten cerebralmalaria |