Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.
HIV-1-specific T lymphocyte responses in individuals exposed to HIV-1 but who remain persistently seronegative (HESNs) have been reported in some but not all previous studies. This study was designed to resolve unequivocally the question of whether HESNs make HIV-1-specific T cell responses. We perf...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797064354479210496 |
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| author | Ritchie, A Campion, S Kopycinski, J Moodie, Z Wang, Z Pandya, K Moore, S Liu, M Brackenridge, S Kuldanek, K Legg, K Cohen, MS Delwart, E Haynes, B Fidler, S Mcmichael, A Goonetilleke, N |
| author_facet | Ritchie, A Campion, S Kopycinski, J Moodie, Z Wang, Z Pandya, K Moore, S Liu, M Brackenridge, S Kuldanek, K Legg, K Cohen, MS Delwart, E Haynes, B Fidler, S Mcmichael, A Goonetilleke, N |
| author_sort | Ritchie, A |
| collection | OXFORD |
| description | HIV-1-specific T lymphocyte responses in individuals exposed to HIV-1 but who remain persistently seronegative (HESNs) have been reported in some but not all previous studies. This study was designed to resolve unequivocally the question of whether HESNs make HIV-1-specific T cell responses. We performed a blind investigation to measure HIV-1-specific T cell responses in both HIV-1-serodiscordant couples and HIV-1-unexposed seronegative controls (HUSNs). We found low-frequency HIV-1-specific T cells in both HESNs and HUSNs but show that the response rates were higher over time in the former (P = 0.01). Furthermore, the magnitudes of the HIV-1-specific T cell responses were significantly higher among responding HESNs than among HUSNs over time (P = 0.002). In both groups, responses were mediated by CD4 T cells. The responses were mapped to single peptides, which often corresponded to epitopes restricted by multiple HLA-DR types that have previously been detected in HIV-1-infected patients. HIV-1-specific T cell responses in HUSNs and some HESNs likely represent cross-reactivity to self or foreign non-HIV-1 antigens. The significantly greater T cell responses in HESNs, including in two who were homozygous for CCR5Δ32, demonstrates that HIV-1-specific T cell responses can be induced or augmented by exposure to HIV-1 without infection. |
| first_indexed | 2024-03-06T21:13:05Z |
| format | Journal article |
| id | oxford-uuid:3ed865b8-0acb-4565-ab8c-93758373a29f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:13:05Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:3ed865b8-0acb-4565-ab8c-93758373a29f2022-03-26T14:28:15ZDifferences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ed865b8-0acb-4565-ab8c-93758373a29fEnglishSymplectic Elements at Oxford2011Ritchie, ACampion, SKopycinski, JMoodie, ZWang, ZPandya, KMoore, SLiu, MBrackenridge, SKuldanek, KLegg, KCohen, MSDelwart, EHaynes, BFidler, SMcmichael, AGoonetilleke, NHIV-1-specific T lymphocyte responses in individuals exposed to HIV-1 but who remain persistently seronegative (HESNs) have been reported in some but not all previous studies. This study was designed to resolve unequivocally the question of whether HESNs make HIV-1-specific T cell responses. We performed a blind investigation to measure HIV-1-specific T cell responses in both HIV-1-serodiscordant couples and HIV-1-unexposed seronegative controls (HUSNs). We found low-frequency HIV-1-specific T cells in both HESNs and HUSNs but show that the response rates were higher over time in the former (P = 0.01). Furthermore, the magnitudes of the HIV-1-specific T cell responses were significantly higher among responding HESNs than among HUSNs over time (P = 0.002). In both groups, responses were mediated by CD4 T cells. The responses were mapped to single peptides, which often corresponded to epitopes restricted by multiple HLA-DR types that have previously been detected in HIV-1-infected patients. HIV-1-specific T cell responses in HUSNs and some HESNs likely represent cross-reactivity to self or foreign non-HIV-1 antigens. The significantly greater T cell responses in HESNs, including in two who were homozygous for CCR5Δ32, demonstrates that HIV-1-specific T cell responses can be induced or augmented by exposure to HIV-1 without infection. |
| spellingShingle | Ritchie, A Campion, S Kopycinski, J Moodie, Z Wang, Z Pandya, K Moore, S Liu, M Brackenridge, S Kuldanek, K Legg, K Cohen, MS Delwart, E Haynes, B Fidler, S Mcmichael, A Goonetilleke, N Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title | Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title_full | Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title_fullStr | Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title_full_unstemmed | Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title_short | Differences in HIV-specific T cell responses between HIV-exposed and -unexposed HIV-seronegative individuals. |
| title_sort | differences in hiv specific t cell responses between hiv exposed and unexposed hiv seronegative individuals |
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