Leptin does not respond to 48 h fat deposition or mobilization in women.
OBJECTIVE: To test the hypothesis that acute responses of plasma leptin concentration to energy balance manipulation are mediated by fat flux. DESIGN: Ten healthy women aged 31-63 y, mass 48-113.5 kg, fat mass 8.5-62.5 kg, were studied for 3 days in a whole-body calorimeter on two occasions. After a...
| Auteurs principaux: | , , , , , , |
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| Format: | Journal article |
| Langue: | English |
| Publié: |
2003
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| _version_ | 1826268663538253824 |
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| author | Murgatroyd, P Frühbeck, G Goldberg, G Jebb, SA Leahy, F Moore, MS Prentice, A |
| author_facet | Murgatroyd, P Frühbeck, G Goldberg, G Jebb, SA Leahy, F Moore, MS Prentice, A |
| author_sort | Murgatroyd, P |
| collection | OXFORD |
| description | OBJECTIVE: To test the hypothesis that acute responses of plasma leptin concentration to energy balance manipulation are mediated by fat flux. DESIGN: Ten healthy women aged 31-63 y, mass 48-113.5 kg, fat mass 8.5-62.5 kg, were studied for 3 days in a whole-body calorimeter on two occasions. After a control day (D1) during which energy balance was maintained, diet was manipulated to induce fat deposition (FD) or mobilization (FM) of 50 g/day for 2 days (D2 and D3). A difference totalling of 194+/-18.6 g fat was achieved between manipulations without significant effects on carbohydrate or protein balance. Fasting plasma leptin was measured on D2 and D4. RESULTS: After the control day plasma leptin concentration averaged 19.01+/-9.8 ng/ml, and was found to be linearly related to body fat mass. After 2 days manipulation of fat balance, leptin concentrations were 21.4+/-10.3 ng/ml (FD) and 21.2+/-11.3 ng/ml (FM). There was no significant difference between treatments in either control day or postmanipulation leptin concentrations, nor did the treatments induce any differences in glucose or insulin concentration responses. CONCLUSION: Although in states of energy balance leptin concentration is linearly related to fat mass, acute modulation of leptin concentration during energy imbalance is not mediated by fat flux. |
| first_indexed | 2024-03-06T21:13:09Z |
| format | Journal article |
| id | oxford-uuid:3edd9c63-c9d8-4750-b8f7-e3204fd8a8cc |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:13:09Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:3edd9c63-c9d8-4750-b8f7-e3204fd8a8cc2022-03-26T14:28:18ZLeptin does not respond to 48 h fat deposition or mobilization in women.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3edd9c63-c9d8-4750-b8f7-e3204fd8a8ccEnglishSymplectic Elements at Oxford2003Murgatroyd, PFrühbeck, GGoldberg, GJebb, SALeahy, FMoore, MSPrentice, AOBJECTIVE: To test the hypothesis that acute responses of plasma leptin concentration to energy balance manipulation are mediated by fat flux. DESIGN: Ten healthy women aged 31-63 y, mass 48-113.5 kg, fat mass 8.5-62.5 kg, were studied for 3 days in a whole-body calorimeter on two occasions. After a control day (D1) during which energy balance was maintained, diet was manipulated to induce fat deposition (FD) or mobilization (FM) of 50 g/day for 2 days (D2 and D3). A difference totalling of 194+/-18.6 g fat was achieved between manipulations without significant effects on carbohydrate or protein balance. Fasting plasma leptin was measured on D2 and D4. RESULTS: After the control day plasma leptin concentration averaged 19.01+/-9.8 ng/ml, and was found to be linearly related to body fat mass. After 2 days manipulation of fat balance, leptin concentrations were 21.4+/-10.3 ng/ml (FD) and 21.2+/-11.3 ng/ml (FM). There was no significant difference between treatments in either control day or postmanipulation leptin concentrations, nor did the treatments induce any differences in glucose or insulin concentration responses. CONCLUSION: Although in states of energy balance leptin concentration is linearly related to fat mass, acute modulation of leptin concentration during energy imbalance is not mediated by fat flux. |
| spellingShingle | Murgatroyd, P Frühbeck, G Goldberg, G Jebb, SA Leahy, F Moore, MS Prentice, A Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title | Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title_full | Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title_fullStr | Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title_full_unstemmed | Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title_short | Leptin does not respond to 48 h fat deposition or mobilization in women. |
| title_sort | leptin does not respond to 48 h fat deposition or mobilization in women |
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