CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.

CD80 cytoplasmic domain controls localization of CD28, CTLA-4, and protein kinase Ctheta in the immunological synapse.

The binding of costimulatory ligand CD80 to CD28 or CTLA-4 on T cells plays an important role in the regulation of the T cell response. We have examined the role of the cytoplasmic domain of CD80 in murine T cell costimulation and its organization in the immunological synapse (IS). Removal of CD80 c...

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Bibliografiske detaljer
Main Authors:	Tseng, S, Liu, M, Dustin, M
Format:	Journal article
Sprog:	English
Udgivet:	2005

Lignende værker

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af: Bruna F. Pinto, et al.
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af: Simon eVille, et al.
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Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation.
af: Kellie J Hall, et al.
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af: Andrea Aprilia, et al.
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af: Dilek Nahzli, et al.
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CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics.
af: van der Merwe, P, et al.
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af: Milstein, O, et al.
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Enfermedad tiroidea autoinmune, ctla-4 y cd 28
af: Silvana Roveto, et al.
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Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation.
af: Hailman, E, et al.
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Rigid, bivalent CTLA-4 binding to CD80 is required to disrupt the cis CD80/PD-L1 interaction
af: Maximillian A. Robinson, et al.
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The immunological synapse.
af: Dustin, M
Udgivet: (2002)

The immunological synapse.
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The immunological synapse
af: Dustin, M
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Membrane domains and the immunological synapse: keeping T cells resting and ready.
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Membrane domains and the immunological synapse: Keeping T cells resting and ready
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T cell-dendritic cell immunological synapses.
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Extraordinary diversity of the CD28/CTLA4 family across jawed vertebrates
af: Sylvie M. A. Quiniou, et al.
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Targeting CD28, CTLA-4 and PD-L1 costimulation differentially controls immune synapses and function of human regulatory and conventional T-cells.
af: Nahzli Dilek, et al.
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Cytotoxic immunological synapses.
af: Dustin, M, et al.
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Self-reactive human CD4 T cell clones form unusual immunological synapses.
af: Schubert, D, et al.
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af: Dustin, M
Udgivet: (2014)

Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse.
af: Castro, M, et al.
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Galectin-3 negatively regulates TCR-mediated CD4+ T-cell activation at the immunological synapse.
af: Chen, H, et al.
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The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28
af: Yannick D. Muller, et al.
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The immunological synapse.
af: Bromley, S, et al.
Udgivet: (2001)

Costimulation: building an immunological synapse.
af: Dustin, M, et al.
Udgivet: (1999)

What is the importance of the immunological synapse?
af: Davis, D, et al.
Udgivet: (2004)

Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens.
af: Beyers, A, et al.
Udgivet: (1991)