Detection of fixed and variable targets in the monkey prefrontal cortex.
Behavioral significance is commonly coded by prefrontal neurons. The significance of a stimulus can be fixed through experience; in complex behavior, however, significance commonly changes with short-term context. To compare these cases, we trained monkeys in 2 versions of visual target detection. I...
| Κύριοι συγγραφείς: | , , , |
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| Μορφή: | Journal article |
| Γλώσσα: | English |
| Έκδοση: |
Oxford University Press
2009
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| _version_ | 1826268668628041728 |
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| author | Kusunoki, M Sigala, N Gaffan, D Duncan, J |
| author_facet | Kusunoki, M Sigala, N Gaffan, D Duncan, J |
| author_sort | Kusunoki, M |
| collection | OXFORD |
| description | Behavioral significance is commonly coded by prefrontal neurons. The significance of a stimulus can be fixed through experience; in complex behavior, however, significance commonly changes with short-term context. To compare these cases, we trained monkeys in 2 versions of visual target detection. In both tasks, animals monitored a series of pictures, making a go response (saccade) at the offset of a specified target picture. In one version, based on "consistent mapping" in human visual search, target and nontarget pictures were fixed throughout training. In the other, based on "varied mapping," a cue at trial onset defined a new target. Building up over the first 1 s following this cue, many cells coded short-term context (cue/target identity) for the current trial. Thereafter, the cell population showed similar coding of behavioral significance in the 2 tasks, with selective early response to targets, and later, sustained activity coding target or nontarget until response. This population similarity was seen despite quite different activity in the 2 tasks for many single cells. At the population level, the results suggest similar prefrontal coding of fixed and short-term behavioral significance. |
| first_indexed | 2024-03-06T21:13:13Z |
| format | Journal article |
| id | oxford-uuid:3ee2ceae-8750-4c1d-a22f-a49ceeb1acb2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:13:13Z |
| publishDate | 2009 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:3ee2ceae-8750-4c1d-a22f-a49ceeb1acb22022-03-26T14:28:28ZDetection of fixed and variable targets in the monkey prefrontal cortex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ee2ceae-8750-4c1d-a22f-a49ceeb1acb2EnglishSymplectic Elements at OxfordOxford University Press2009Kusunoki, MSigala, NGaffan, DDuncan, JBehavioral significance is commonly coded by prefrontal neurons. The significance of a stimulus can be fixed through experience; in complex behavior, however, significance commonly changes with short-term context. To compare these cases, we trained monkeys in 2 versions of visual target detection. In both tasks, animals monitored a series of pictures, making a go response (saccade) at the offset of a specified target picture. In one version, based on "consistent mapping" in human visual search, target and nontarget pictures were fixed throughout training. In the other, based on "varied mapping," a cue at trial onset defined a new target. Building up over the first 1 s following this cue, many cells coded short-term context (cue/target identity) for the current trial. Thereafter, the cell population showed similar coding of behavioral significance in the 2 tasks, with selective early response to targets, and later, sustained activity coding target or nontarget until response. This population similarity was seen despite quite different activity in the 2 tasks for many single cells. At the population level, the results suggest similar prefrontal coding of fixed and short-term behavioral significance. |
| spellingShingle | Kusunoki, M Sigala, N Gaffan, D Duncan, J Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title | Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title_full | Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title_fullStr | Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title_full_unstemmed | Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title_short | Detection of fixed and variable targets in the monkey prefrontal cortex. |
| title_sort | detection of fixed and variable targets in the monkey prefrontal cortex |
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