"Infectious" transplantation tolerance.
The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had be...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1826268669915693056 |
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| author | Qin, S Cobbold, S Pope, H Elliott, J Kioussis, D Davies, J Waldmann, H |
| author_facet | Qin, S Cobbold, S Pope, H Elliott, J Kioussis, D Davies, J Waldmann, H |
| author_sort | Qin, S |
| collection | OXFORD |
| description | The maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance. |
| first_indexed | 2024-03-06T21:13:14Z |
| format | Journal article |
| id | oxford-uuid:3ee4ecbc-bb29-4354-82ed-ce674aa2f897 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:13:14Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:3ee4ecbc-bb29-4354-82ed-ce674aa2f8972022-03-26T14:28:31Z"Infectious" transplantation tolerance.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3ee4ecbc-bb29-4354-82ed-ce674aa2f897EnglishSymplectic Elements at Oxford1993Qin, SCobbold, SPope, HElliott, JKioussis, DDavies, JWaldmann, HThe maintenance of transplantation tolerance induced in adult mice after short-term treatment with nonlytic monoclonal antibodies to CD4 and CD8 was investigated. CD4+ T cells from tolerant mice disabled naïve lymphocytes so that they too could not reject the graft. The naïve lymphocytes that had been so disabled also became tolerant and, in turn, developed the capacity to specifically disable other naïve lymphocytes. This process of "infectious" tolerance explains why no further immunosuppression was needed to maintain long-term transplantation tolerance. |
| spellingShingle | Qin, S Cobbold, S Pope, H Elliott, J Kioussis, D Davies, J Waldmann, H "Infectious" transplantation tolerance. |
| title | "Infectious" transplantation tolerance. |
| title_full | "Infectious" transplantation tolerance. |
| title_fullStr | "Infectious" transplantation tolerance. |
| title_full_unstemmed | "Infectious" transplantation tolerance. |
| title_short | "Infectious" transplantation tolerance. |
| title_sort | infectious transplantation tolerance |
| work_keys_str_mv | AT qins infectioustransplantationtolerance AT cobbolds infectioustransplantationtolerance AT popeh infectioustransplantationtolerance AT elliottj infectioustransplantationtolerance AT kioussisd infectioustransplantationtolerance AT daviesj infectioustransplantationtolerance AT waldmannh infectioustransplantationtolerance |