Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments

Background: Enhanced macromolecule biosynthesis is integral to growth and proliferation of cancer cells. Lipid biosynthesis has been predicted to be an essential process in cancer cells. However, it is unclear which enzymes within this pathway offer the best selectivity for cancer cells and could be...

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Detalles Bibliográficos
Main Authors: Peck, B, Schug, Z, Zhang, Q, Dankworth, B, Jones, D, Smethurst, E, Patel, R, Mason, S, Jiang, M, Saunders, R, Howell, M, Mitter, R, Spencer-Dene, B, Stamp, G, McGarry, L, James, D, Shanks, E, Aboagye, E, Critchlow, S, Leung, H, Harris, A, Wakelam, M, Gottlieb, E, Schulze, A
Formato: Journal article
Idioma:English
Publicado: BioMed Central 2016