Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey.
BACKGROUND: We investigated relationships between early growth and proximal femoral geometry at age 6 y in a prospective population-based cohort, the Southampton Women's Survey. METHODS: In 493 mother-offspring pairs, we assessed linear size using high-resolution ultrasound at 11, 19, and 34 wk...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2013
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| _version_ | 1797064410684981248 |
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| author | Harvey, N Cole, Z Crozier, SR Ntani, G Mahon, P Robinson, S Inskip, H Godfrey, K Dennison, E Cooper, C |
| author_facet | Harvey, N Cole, Z Crozier, SR Ntani, G Mahon, P Robinson, S Inskip, H Godfrey, K Dennison, E Cooper, C |
| author_sort | Harvey, N |
| collection | OXFORD |
| description | BACKGROUND: We investigated relationships between early growth and proximal femoral geometry at age 6 y in a prospective population-based cohort, the Southampton Women's Survey. METHODS: In 493 mother-offspring pairs, we assessed linear size using high-resolution ultrasound at 11, 19, and 34 wk gestation (femur length) and at birth and 1, 2, 3, 4, and 6 y (crown-heel length/height). SD scores were created and conditional regression modeling generated mutually independent growth variables. Children underwent hip dual-energy X-ray absorptiometry (DXA) at 6 y; hip structure analysis software yielded measures of geometry and strength. RESULTS: There were strong associations between early linear growth and femoral neck section modulus (Z) at 6 y, with the strongest relationships observed for femur growth from 19 to 34 wk gestation (β = 0.26 cm(3)/SD, P < 0.0001), and for height growth from birth to 1 y (β = 0.25 cm(3)/SD, P < 0.0001) and 1 to 2 y (β = 0.33 cm(3)/SD, P < 0.0001), with progressively weaker relationships over years 3 (β = 0.23 cm(3)/SD, P = 0.0002) and 4 (β = 0.10 cm(3)/SD, P = 0.18). CONCLUSION: These results demonstrate that growth before age 3 y predicts proximal femoral geometry at 6 y old. These data suggest critical periods in which there is capacity for long-term influence on the later skeletal growth trajectory. |
| first_indexed | 2024-03-06T21:13:54Z |
| format | Journal article |
| id | oxford-uuid:3f1dc79f-15f4-4620-aa9a-c9676a461e93 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:13:54Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:3f1dc79f-15f4-4620-aa9a-c9676a461e932022-03-26T14:29:53ZFetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f1dc79f-15f4-4620-aa9a-c9676a461e93EnglishSymplectic Elements at Oxford2013Harvey, NCole, ZCrozier, SRNtani, GMahon, PRobinson, SInskip, HGodfrey, KDennison, ECooper, CBACKGROUND: We investigated relationships between early growth and proximal femoral geometry at age 6 y in a prospective population-based cohort, the Southampton Women's Survey. METHODS: In 493 mother-offspring pairs, we assessed linear size using high-resolution ultrasound at 11, 19, and 34 wk gestation (femur length) and at birth and 1, 2, 3, 4, and 6 y (crown-heel length/height). SD scores were created and conditional regression modeling generated mutually independent growth variables. Children underwent hip dual-energy X-ray absorptiometry (DXA) at 6 y; hip structure analysis software yielded measures of geometry and strength. RESULTS: There were strong associations between early linear growth and femoral neck section modulus (Z) at 6 y, with the strongest relationships observed for femur growth from 19 to 34 wk gestation (β = 0.26 cm(3)/SD, P < 0.0001), and for height growth from birth to 1 y (β = 0.25 cm(3)/SD, P < 0.0001) and 1 to 2 y (β = 0.33 cm(3)/SD, P < 0.0001), with progressively weaker relationships over years 3 (β = 0.23 cm(3)/SD, P = 0.0002) and 4 (β = 0.10 cm(3)/SD, P = 0.18). CONCLUSION: These results demonstrate that growth before age 3 y predicts proximal femoral geometry at 6 y old. These data suggest critical periods in which there is capacity for long-term influence on the later skeletal growth trajectory. |
| spellingShingle | Harvey, N Cole, Z Crozier, SR Ntani, G Mahon, P Robinson, S Inskip, H Godfrey, K Dennison, E Cooper, C Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title | Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title_full | Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title_fullStr | Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title_full_unstemmed | Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title_short | Fetal and infant growth predict hip geometry at 6 y old: findings from the Southampton Women's Survey. |
| title_sort | fetal and infant growth predict hip geometry at 6 y old findings from the southampton women s survey |
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