Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques

Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 an...

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मुख्य लेखकों: Miller, K, McNab, J, Jbabdi, S, Douaud, G
स्वरूप: Journal article
भाषा:English
प्रकाशित: 2012
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author Miller, K
McNab, J
Jbabdi, S
Douaud, G
author_facet Miller, K
McNab, J
Jbabdi, S
Douaud, G
author_sort Miller, K
collection OXFORD
description Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. © 2011 Elsevier Inc.
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spelling oxford-uuid:3f1e2f69-128b-4048-8d0d-fa4a2272cc2d2022-03-26T14:29:58ZDiffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniquesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f1e2f69-128b-4048-8d0d-fa4a2272cc2dEnglishSymplectic Elements at Oxford2012Miller, KMcNab, JJbabdi, SDouaud, GDiffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. © 2011 Elsevier Inc.
spellingShingle Miller, K
McNab, J
Jbabdi, S
Douaud, G
Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title_full Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title_fullStr Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title_full_unstemmed Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title_short Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
title_sort diffusion tractography of post mortem human brains optimization and comparison of spin echo and steady state free precession techniques
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AT jbabdis diffusiontractographyofpostmortemhumanbrainsoptimizationandcomparisonofspinechoandsteadystatefreeprecessiontechniques
AT douaudg diffusiontractographyofpostmortemhumanbrainsoptimizationandcomparisonofspinechoandsteadystatefreeprecessiontechniques