Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques
Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 an...
मुख्य लेखकों: | , , , |
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स्वरूप: | Journal article |
भाषा: | English |
प्रकाशित: |
2012
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_version_ | 1826268718295941120 |
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author | Miller, K McNab, J Jbabdi, S Douaud, G |
author_facet | Miller, K McNab, J Jbabdi, S Douaud, G |
author_sort | Miller, K |
collection | OXFORD |
description | Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. © 2011 Elsevier Inc. |
first_indexed | 2024-03-06T21:13:54Z |
format | Journal article |
id | oxford-uuid:3f1e2f69-128b-4048-8d0d-fa4a2272cc2d |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T21:13:54Z |
publishDate | 2012 |
record_format | dspace |
spelling | oxford-uuid:3f1e2f69-128b-4048-8d0d-fa4a2272cc2d2022-03-26T14:29:58ZDiffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniquesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f1e2f69-128b-4048-8d0d-fa4a2272cc2dEnglishSymplectic Elements at Oxford2012Miller, KMcNab, JJbabdi, SDouaud, GDiffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of protocols and conditions. DW-SE and DW-SSFP data in a whole, post-mortem human brain are compared for 6- and 12-hour scan durations. Tractography is performed in major projection, commissural and association tracts (corticospinal tract, corpus callosum, superior longitudinal fasciculus and cingulum bundle). The results demonstrate superior tract-tracing from DW-SSFP data, with 6-hour DW-SSFP data performing as well as or better than 12-hour DW-SE scans. These results suggest that DW-SSFP may be a preferred method for diffusion imaging of post-mortem human brains. The ability to estimate multiple fibers in imaging voxels is also demonstrated, again with greater success in DW-SSFP data. © 2011 Elsevier Inc. |
spellingShingle | Miller, K McNab, J Jbabdi, S Douaud, G Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_full | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_fullStr | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_full_unstemmed | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_short | Diffusion tractography of post-mortem human brains: Optimization and comparison of spin echo and steady-state free precession techniques |
title_sort | diffusion tractography of post mortem human brains optimization and comparison of spin echo and steady state free precession techniques |
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