CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.

CD103+ tumor-infiltrating lymphocytes are tumor-reactive intraepithelial CD8+ T cells associated with prognostic benefit and therapy response in cervical cancer.

Human papilloma virus (HPV)-induced cervical cancer constitutively expresses viral E6/E7 oncoproteins and is an excellent target for T cell-based immunotherapy. However, not all tumor-infiltrating T cells confer equal benefit to patients, with epithelial T cells being superior to stromal T cells. To...

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Hlavní autoři: Komdeur, F, Prins, T, van de Wall, S, Plat, A, Wisman, G, Hollema, H, Daemen, T, Church, D, de Bruyn, M, Nijman, H
Médium: Journal article
Jazyk:English
Vydáno: Taylor and Francis 2017

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