Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy

Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy

<p>Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids.</p> <p>Arylamine...

Bibliográfalaš dieđut
Váldodahkki:	Abuhammad, A
Eará dahkkit:	Sim, E
Materiálatiipa:	Oahppočájánas
Giella:	English
Almmustuhtton:	2013
Fáttát:	Pharmacology Medical sciences

Geahča maid

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
Dahkki: Westwood, I, et al.
Almmustuhtton: (2010)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
Dahkki: Abuhammad, A, et al.
Almmustuhtton: (2012)

Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
Dahkki: Abuhammad, A, et al.
Almmustuhtton: (2010)

Investigating the endogenous role of human n-acetyltransferase 1, as potential breast cancer biomarker, using chemical biology
Dahkki: Laurieri, N
Almmustuhtton: (2012)

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.
Dahkki: Sandy, J, et al.
Almmustuhtton: (2002)

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
Dahkki: Fullam, E, et al.
Almmustuhtton: (2011)

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
Dahkki: Fullam, E, et al.
Almmustuhtton: (2009)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
Dahkki: Abuhammad, A, et al.
Almmustuhtton: (2010)

Mapping the genes for arylamine N-acetyltransferases
Dahkki: Fakis, G
Almmustuhtton: (2000)

Structure and mechanism of arylamine N-acetyltransferases.
Dahkki: Westwood, I, et al.
Almmustuhtton: (2006)

Arylamine N-acetyltransferase in adult mouse brain
Dahkki: Mo, M, et al.
Almmustuhtton: (2004)

Expression of the genes for arylamine N-acetyltransferases in mice
Dahkki: Boukouvala, S, et al.
Almmustuhtton: (2002)

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.
Dahkki: Kawamura, A, et al.
Almmustuhtton: (2003)

Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
Dahkki: Wakefield, L, et al.
Almmustuhtton: (2006)

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
Dahkki: Sim, E, et al.
Almmustuhtton: (2008)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
Dahkki: Russell, A, et al.
Almmustuhtton: (2009)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
Dahkki: Laurieri, N, et al.
Almmustuhtton: (2014)

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
Dahkki: Kawamura, A, et al.
Almmustuhtton: (2005)

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
Dahkki: Brooke, E, et al.
Almmustuhtton: (2003)

Arylamine N-acetyltransferase expression during murine heart development
Dahkki: Wakefield, L, et al.
Almmustuhtton: (2004)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
Dahkki: Hiba Chelouti, et al.
Almmustuhtton: (2017-08-01)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
Dahkki: Madikane, V, et al.
Almmustuhtton: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
Dahkki: Madikane, V, et al.
Almmustuhtton: (2007)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
Dahkki: Brooke, E
Almmustuhtton: (2003)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
Dahkki: Amjad Mahasneh, et al.
Almmustuhtton: (2012-01-01)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
Dahkki: Kawamura, A, et al.
Almmustuhtton: (2004)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
Dahkki: Wang, H, et al.
Almmustuhtton: (2005)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
Dahkki: Mark A. Doll, et al.
Almmustuhtton: (2017-07-01)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
Dahkki: Anderton, M, et al.
Almmustuhtton: (2006)

Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG
Dahkki: Eltis, E
Almmustuhtton: (2006)

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.
Dahkki: Abuhammad, A, et al.
Almmustuhtton: (2013)

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
Dahkki: Brooke, E, et al.
Almmustuhtton: (2003)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
Dahkki: Westwood, I, et al.
Almmustuhtton: (2011)

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
Dahkki: Eneida Turiján-Espinoza, et al.
Almmustuhtton: (2018-03-01)

Network pharmacology and in silico investigation into the therapeutic potential of phytoconstituents of Peucedanum ostruthium as anti-tubercular agents
Dahkki: Neeru Bhanwala, et al.
Almmustuhtton: (2025-03-01)

Pathogenic mycobacteria achieve cellular persistence via lipid-mediated inhibition of the Niemann-Pick disease type C pathway
Dahkki: Fineran, PD
Almmustuhtton: (2014)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
Dahkki: Laurieri, N, et al.
Almmustuhtton: (2010)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
Dahkki: Wakefield, L, et al.
Almmustuhtton: (2008)

Arylamine N-acetyltransferase-1 is highly expressed in breast cancers and conveys enhanced growth and resistance to etoposide in vitro.
Dahkki: Adam, P, et al.
Almmustuhtton: (2003)

Dataset for proteomic analysis of arylamine N-acetyltransferase 1 knockout MDA-MB-231 breast cancer cells
Dahkki: Kyung U. Hong, et al.
Almmustuhtton: (2022-12-01)