Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy

Arylamine N-Acetyltransferases from mycobacteria: investigations of a potential yarget for anti-tubercular therapy

<p>Reactivation of latent infection is the major cause of tuberculosis (TB). Cholesterol is a critical carbon source during latent infection. Catabolism of cholesterol contributes to the pool of propionyl-CoA, a precursor that is incorporated into cell-wall lipids.</p> <p>Arylamine...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Abuhammad, A
Awduron Eraill:	Sim, E
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2013
Pynciau:	Pharmacology Medical sciences

Eitemau Tebyg

Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars.
gan: Westwood, I, et al.
Cyhoeddwyd: (2010)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages
gan: Abuhammad, A, et al.
Cyhoeddwyd: (2012)

Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages.
gan: Areej Abuhammad, et al.
Cyhoeddwyd: (2012-01-01)

Structural Studies on the Mycobacterial Arylamine N-Acetyltransferases
gan: Abuhammad, A, et al.
Cyhoeddwyd: (2010)

Investigating the endogenous role of human n-acetyltransferase 1, as potential breast cancer biomarker, using chemical biology
gan: Laurieri, N
Cyhoeddwyd: (2012)

The structure of arylamine N-acetyltransferase from Mycobacterium smegmatis--an enzyme which inactivates the anti-tubercular drug, isoniazid.
gan: Sandy, J, et al.
Cyhoeddwyd: (2002)

Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase.
gan: Fullam, E, et al.
Cyhoeddwyd: (2011)

Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis.
gan: Fullam, E, et al.
Cyhoeddwyd: (2009)

Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site.
gan: Abuhammad, A, et al.
Cyhoeddwyd: (2010)

Mapping the genes for arylamine N-acetyltransferases
gan: Fakis, G
Cyhoeddwyd: (2000)

Structure and mechanism of arylamine N-acetyltransferases.
gan: Westwood, I, et al.
Cyhoeddwyd: (2006)

Arylamine N-acetyltransferase in adult mouse brain
gan: Mo, M, et al.
Cyhoeddwyd: (2004)

Expression of the genes for arylamine N-acetyltransferases in mice
gan: Boukouvala, S, et al.
Cyhoeddwyd: (2002)

Structural investigation of mutant Mycobacterium smegmatis arylamine N-acetyltransferase: a model for a naturally occurring functional polymorphism in Mycobacterium tuberculosis arylamine N-acetyltransferase.
gan: Kawamura, A, et al.
Cyhoeddwyd: (2003)

Neuroendocrine expression of mouse arylamine N-acetyltransferase 2
gan: Wakefield, L, et al.
Cyhoeddwyd: (2006)

Arylamine N-acetyltransferases: structural and functional implications of polymorphisms.
gan: Sim, E, et al.
Cyhoeddwyd: (2008)

Selective small molecule inhibitors of the potential breast cancer marker, human arylamine N-acetyltransferase 1, and its murine homologue, mouse arylamine N-acetyltransferase 2.
gan: Russell, A, et al.
Cyhoeddwyd: (2009)

Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding
gan: Laurieri, N, et al.
Cyhoeddwyd: (2014)

Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening.
gan: Kawamura, A, et al.
Cyhoeddwyd: (2005)

An approach to identifying novel substrates of bacterial arylamine N-acetyltransferases.
gan: Brooke, E, et al.
Cyhoeddwyd: (2003)

Arylamine N-acetyltransferase expression during murine heart development
gan: Wakefield, L, et al.
Cyhoeddwyd: (2004)

Arylamine N-acetyltransferase 2 gene polymorphism in an Algerian population
gan: Hiba Chelouti, et al.
Cyhoeddwyd: (2017-08-01)

Biochemical Characterization of Arylamine N-acetyltransferases From Vibrio vulnificus
gan: Xinning Liu, et al.
Cyhoeddwyd: (2021-01-01)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris.
gan: Madikane, V, et al.
Cyhoeddwyd: (2007)

Inhibition of mycobacterial arylamine N-acetyltransferase contributes to anti-mycobacterial activity of Warburgia salutaris
gan: Madikane, V, et al.
Cyhoeddwyd: (2007)

Protein-ligand interactions of arylamine N-acetyltransferase from Mycobacterium smegmatis
gan: Brooke, E
Cyhoeddwyd: (2003)

Polymorphisms of arylamine N-acetyltransferase2 and risk of lung and colorectal cancer
gan: Amjad Mahasneh, et al.
Cyhoeddwyd: (2012-01-01)

Hamster arylamine N-acetyltransferase 2: Investigation of substrate specificity by high-through-put screening
gan: Kawamura, A, et al.
Cyhoeddwyd: (2004)

Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1.
gan: Wang, H, et al.
Cyhoeddwyd: (2005)

Arylamine N-acetyltransferase 2 genotype-dependent N-acetylation of isoniazid in cryopreserved human hepatocytes
gan: Mark A. Doll, et al.
Cyhoeddwyd: (2017-07-01)

Characterization of the putative operon containing arylamine N-acetyltransferase (nat) in Mycobacterium bovis BCG.
gan: Anderton, M, et al.
Cyhoeddwyd: (2006)

Characterization of the putative operon containing arylamine N−acetyltransferase (nat) in Mycobacterium bovis BCG
gan: Eltis, E
Cyhoeddwyd: (2006)

Structure of arylamine N-acetyltransferase from Mycobacterium tuberculosis determined by cross-seeding with the homologous protein from M. marinum: triumph over adversity.
gan: Abuhammad, A, et al.
Cyhoeddwyd: (2013)

Pathogenic mycobacteria achieve cellular persistence via lipid-mediated inhibition of the Niemann-Pick disease type C pathway
gan: Fineran, PD
Cyhoeddwyd: (2014)

Network pharmacology and in silico investigation into the therapeutic potential of phytoconstituents of Peucedanum ostruthium as anti-tubercular agents
gan: Neeru Bhanwala, et al.
Cyhoeddwyd: (2025-03-01)

Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
gan: Brooke, E, et al.
Cyhoeddwyd: (2003)

Novel small-molecule inhibitors of arylamine N-acetyltransferases: drug discovery by high-throughput screening.
gan: Westwood, I, et al.
Cyhoeddwyd: (2011)

A pilot study of the modulation of sirtuins on arylamine N-acetyltransferase 1 and 2 enzymatic activity
gan: Eneida Turiján-Espinoza, et al.
Cyhoeddwyd: (2018-03-01)

Small molecule colorimetric probes for specific detection of human arylamine N-acetyltransferase 1, a potential breast cancer biomarker.
gan: Laurieri, N, et al.
Cyhoeddwyd: (2010)

Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.
gan: Wakefield, L, et al.
Cyhoeddwyd: (2008)