Germline mutations but not somatic changes at the MYH locus contribute to the pathogenesis of unselected colorectal cancers.

MYH-associated polyposis is a recently described, autosomal recessive condition comprising multiple colorectal adenomas and cancer. This disease is caused by germline mutations in the base excision repair (BER) gene MYH. Genes involved in the BER pathway are thus good candidates for involvement in t...

詳細記述

書誌詳細
主要な著者: Halford, SE, Rowan, A, Lipton, L, Sieber, O, Pack, K, Thomas, H, Hodgson, S, Bodmer, W, Tomlinson, I
フォーマット: Journal article
言語:English
出版事項: 2003