IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.

Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this r...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors: Cohen, S, Katsikis, P, Feldmann, M, Londei, M
Format: Journal article
Sprog:English
Udgivet: 1994
_version_ 1826268775125614592
author Cohen, S
Katsikis, P
Feldmann, M
Londei, M
author_facet Cohen, S
Katsikis, P
Feldmann, M
Londei, M
author_sort Cohen, S
collection OXFORD
description Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha beta and gamma delta T-cell receptor (TCR)-expressing cells. This up-regulation of CD25 was accompanied by an increase in the T cells IL-2-dependent proliferative response in 63% of the CD4+ clones and 100% of the CD8+, CD4-, CD8- alpha beta and gamma delta TCR+ clones analysed. IL-10 was also shown to be at least partly responsible for the up-regulation of CD25 on mitogen-activated peripheral blood mononuclear cells, suggesting that IL-10 has this CD25 modulatory effect within a more physiological environment. Our data suggest that IL-10 can have a multitude of effects on human T cells, and should not be considered exclusively as an immunoinhibitory cytokine.
first_indexed 2024-03-06T21:14:47Z
format Journal article
id oxford-uuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63c
institution University of Oxford
language English
last_indexed 2024-03-06T21:14:47Z
publishDate 1994
record_format dspace
spelling oxford-uuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63c2022-03-26T14:31:51ZIL-10 enhances expression of the IL-2 receptor alpha chain on T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63cEnglishSymplectic Elements at Oxford1994Cohen, SKatsikis, PFeldmann, MLondei, MInterleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha beta and gamma delta T-cell receptor (TCR)-expressing cells. This up-regulation of CD25 was accompanied by an increase in the T cells IL-2-dependent proliferative response in 63% of the CD4+ clones and 100% of the CD8+, CD4-, CD8- alpha beta and gamma delta TCR+ clones analysed. IL-10 was also shown to be at least partly responsible for the up-regulation of CD25 on mitogen-activated peripheral blood mononuclear cells, suggesting that IL-10 has this CD25 modulatory effect within a more physiological environment. Our data suggest that IL-10 can have a multitude of effects on human T cells, and should not be considered exclusively as an immunoinhibitory cytokine.
spellingShingle Cohen, S
Katsikis, P
Feldmann, M
Londei, M
IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title_full IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title_fullStr IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title_full_unstemmed IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title_short IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
title_sort il 10 enhances expression of the il 2 receptor alpha chain on t cells
work_keys_str_mv AT cohens il10enhancesexpressionoftheil2receptoralphachainontcells
AT katsikisp il10enhancesexpressionoftheil2receptoralphachainontcells
AT feldmannm il10enhancesexpressionoftheil2receptoralphachainontcells
AT londeim il10enhancesexpressionoftheil2receptoralphachainontcells