IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this r...
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Format: | Journal article |
Sprog: | English |
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1994
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author | Cohen, S Katsikis, P Feldmann, M Londei, M |
author_facet | Cohen, S Katsikis, P Feldmann, M Londei, M |
author_sort | Cohen, S |
collection | OXFORD |
description | Interleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha beta and gamma delta T-cell receptor (TCR)-expressing cells. This up-regulation of CD25 was accompanied by an increase in the T cells IL-2-dependent proliferative response in 63% of the CD4+ clones and 100% of the CD8+, CD4-, CD8- alpha beta and gamma delta TCR+ clones analysed. IL-10 was also shown to be at least partly responsible for the up-regulation of CD25 on mitogen-activated peripheral blood mononuclear cells, suggesting that IL-10 has this CD25 modulatory effect within a more physiological environment. Our data suggest that IL-10 can have a multitude of effects on human T cells, and should not be considered exclusively as an immunoinhibitory cytokine. |
first_indexed | 2024-03-06T21:14:47Z |
format | Journal article |
id | oxford-uuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63c |
institution | University of Oxford |
language | English |
last_indexed | 2024-03-06T21:14:47Z |
publishDate | 1994 |
record_format | dspace |
spelling | oxford-uuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63c2022-03-26T14:31:51ZIL-10 enhances expression of the IL-2 receptor alpha chain on T cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f66f47f-9a58-4f2e-a66a-9501a85ac63cEnglishSymplectic Elements at Oxford1994Cohen, SKatsikis, PFeldmann, MLondei, MInterleukin-10 (IL-10) has various immunomodulatory actions depending on the target cell type. Some of these effects have been shown to be owing to its ability to down-regulate surface expression of markers, for example HLA-DR on macrophages and CD25 (IL-2 receptor alpha chain) on B cells. In this report we show that preincubation of IL-10 for 24 hr up-regulates expression of the activation marker CD25, but not HLA-DR on cloned T cells of various phenotypes such as CD4+, CD8+, CD4- CD8- alpha beta and gamma delta T-cell receptor (TCR)-expressing cells. This up-regulation of CD25 was accompanied by an increase in the T cells IL-2-dependent proliferative response in 63% of the CD4+ clones and 100% of the CD8+, CD4-, CD8- alpha beta and gamma delta TCR+ clones analysed. IL-10 was also shown to be at least partly responsible for the up-regulation of CD25 on mitogen-activated peripheral blood mononuclear cells, suggesting that IL-10 has this CD25 modulatory effect within a more physiological environment. Our data suggest that IL-10 can have a multitude of effects on human T cells, and should not be considered exclusively as an immunoinhibitory cytokine. |
spellingShingle | Cohen, S Katsikis, P Feldmann, M Londei, M IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title | IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title_full | IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title_fullStr | IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title_full_unstemmed | IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title_short | IL-10 enhances expression of the IL-2 receptor alpha chain on T cells. |
title_sort | il 10 enhances expression of the il 2 receptor alpha chain on t cells |
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