Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.

Disruption of a conserved region of Xist exon 1 impairs Xist RNA localisation and X-linked gene silencing during random and imprinted X chromosome inactivation.

In XX female mammals a single X chromosome is inactivated early in embryonic development, a process that is required to equalise X-linked gene dosage relative to XY males. X inactivation is regulated by a cis-acting master switch, the Xist locus, the product of which is a large non-coding RNA that c...

Bibliografske podrobnosti
Main Authors:	Senner, C, Nesterova, T, Norton, S, Dewchand, H, Godwin, J, Mak, W, Brockdorff, N
Format:	Journal article
Jezik:	English
Izdano:	2011

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