The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study
<p>AIMS: The age-thrombus score-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic res...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Europa Digital & Publishing
2017
|
| _version_ | 1797064490203742208 |
|---|---|
| author | De Maria, G Alkhalil, M Wolfrum, M Fahrni, G Borlotti, A Gaughran, L Dawkins, S Langrish, J Lucking, A Choudhury, R Porto, I Crea, F Dall'Armellina, E Channon, K Kharbanda, R Banning, A |
| author_facet | De Maria, G Alkhalil, M Wolfrum, M Fahrni, G Borlotti, A Gaughran, L Dawkins, S Langrish, J Lucking, A Choudhury, R Porto, I Crea, F Dall'Armellina, E Channon, K Kharbanda, R Banning, A |
| author_sort | De Maria, G |
| collection | OXFORD |
| description | <p>AIMS: The age-thrombus score-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six months follow up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using Age ( >50 = 1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100 = 1 point; ≥100 = 2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI0-1: 16.5% [8.7 - 22.9], ATI2-3: 28.5% [15.5 - 35.0], ATI4-5-6: 35.5% [22.2 - 44.4], p: 0.001) and with MVO% (ATI0-1: 0.0% [0.0-0.9], ATI2-3: 0.7% [0.0-2.5] and ATI4-5-6: 4.1% [1.2-10.7], p< 0.001). Furthermore, ATI score predicted final IS% at six months follow up (ATI0-1: 12.7% [4.1 - 18.0], ATI2-3-: 16.30% [8.0 - 24.7], ATI4-5-6: 29.5% [19.9 - 49.5], p: 0.02). CONCLUSIONS: The ATI score performed prior to stenting in patients with STEMI, can predict the likelihood of MVO% and IS% both acutely and at six months follow up cMRI.</p> |
| first_indexed | 2024-03-06T21:15:04Z |
| format | Journal article |
| id | oxford-uuid:3f81595f-87bb-4620-a1c5-7ee9660c0100 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:15:04Z |
| publishDate | 2017 |
| publisher | Europa Digital & Publishing |
| record_format | dspace |
| spelling | oxford-uuid:3f81595f-87bb-4620-a1c5-7ee9660c01002022-03-26T14:32:31ZThe ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation studyJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:3f81595f-87bb-4620-a1c5-7ee9660c0100EnglishSymplectic Elements at OxfordEuropa Digital & Publishing2017De Maria, GAlkhalil, MWolfrum, MFahrni, GBorlotti, AGaughran, LDawkins, SLangrish, JLucking, AChoudhury, RPorto, ICrea, FDall'Armellina, EChannon, KKharbanda, RBanning, A <p>AIMS: The age-thrombus score-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six months follow up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using Age ( >50 = 1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100 = 1 point; ≥100 = 2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI0-1: 16.5% [8.7 - 22.9], ATI2-3: 28.5% [15.5 - 35.0], ATI4-5-6: 35.5% [22.2 - 44.4], p: 0.001) and with MVO% (ATI0-1: 0.0% [0.0-0.9], ATI2-3: 0.7% [0.0-2.5] and ATI4-5-6: 4.1% [1.2-10.7], p< 0.001). Furthermore, ATI score predicted final IS% at six months follow up (ATI0-1: 12.7% [4.1 - 18.0], ATI2-3-: 16.30% [8.0 - 24.7], ATI4-5-6: 29.5% [19.9 - 49.5], p: 0.02). CONCLUSIONS: The ATI score performed prior to stenting in patients with STEMI, can predict the likelihood of MVO% and IS% both acutely and at six months follow up cMRI.</p> |
| spellingShingle | De Maria, G Alkhalil, M Wolfrum, M Fahrni, G Borlotti, A Gaughran, L Dawkins, S Langrish, J Lucking, A Choudhury, R Porto, I Crea, F Dall'Armellina, E Channon, K Kharbanda, R Banning, A The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title | The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title_full | The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title_fullStr | The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title_full_unstemmed | The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title_short | The ATI score (Age-Thrombotic burden-Index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST elevation myocardial infarction: a cardiac magnetic resonance validation study |
| title_sort | ati score age thrombotic burden index of microcirculatory resistance determined during primary percutaneous coronary intervention predicts final infarct size in patients with st elevation myocardial infarction a cardiac magnetic resonance validation study |
| work_keys_str_mv | AT demariag theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT alkhalilm theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT wolfrumm theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT fahrnig theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT borlottia theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT gaughranl theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT dawkinss theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT langrishj theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT luckinga theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT choudhuryr theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT portoi theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT creaf theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT dallarmellinae theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT channonk theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT kharbandar theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT banninga theatiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT demariag atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT alkhalilm atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT wolfrumm atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT fahrnig atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT borlottia atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT gaughranl atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT dawkinss atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT langrishj atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT luckinga atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT choudhuryr atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT portoi atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT creaf atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT dallarmellinae atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT channonk atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT kharbandar atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy AT banninga atiscoreagethromboticburdenindexofmicrocirculatoryresistancedeterminedduringprimarypercutaneouscoronaryinterventionpredictsfinalinfarctsizeinpatientswithstelevationmyocardialinfarctionacardiacmagneticresonancevalidationstudy |