The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers. Intra-chromosomal DNA double-strand break (DSB) joining events during immunoglobulin class switch recombination (CSR) require 53BP1. However, in BRCA...

Full description

Bibliographic Details
Main Authors:	Becker, JR, Cuella-Martin, R, Barazas, M, Liu, R, Oliveira, C, Oliver, AW, Bilham, K, Holt, AB, Blackford, AN, Heierhorst, J, Jonkers, J, Rottenberg, S, Chapman, JR
Format:	Journal article
Published:	Springer Nature 2018

Similar Items

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma
by: David M. Wong, et al.
Published: (2016-02-01)

Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
by: Sabine Jurado, et al.
Published: (2010-10-01)

Correction: Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis.
by: Sabine Jurado, et al.
Published: (2010-11-01)

BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance
by: Joseph Nacson, et al.
Published: (2018-09-01)

Telomere-Internal Double-Strand Breaks Are Repaired by Homologous Recombination and PARP1/Lig3-Dependent End-Joining
by: Ylli Doksani, et al.
Published: (2016-11-01)

Digitor/dASCIZ Has Multiple Roles in Drosophila Development.
by: Saheli Sengupta, et al.
Published: (2016-01-01)

DLEU1 promotes cell survival by preventing DYNLL1 degradation in esophageal squamous cell carcinoma
by: Qihang Li, et al.
Published: (2022-05-01)

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells
by: Schoonen, P, et al.
Published: (2017)

The CST complex mediates end protection at double-strand breaks and promotes PARP inhibitor sensitivity in BRCA1-deficient cells
by: Barazas, M, et al.
Published: (2018)

Correction: Dual Functions of ASCIZ in the DNA Base Damage Response and Pulmonary Organogenesis
Published: (2010-11-01)

WIP1 Promotes Homologous Recombination and Modulates Sensitivity to PARP Inhibitors
by: Kamila Burdova, et al.
Published: (2019-10-01)

Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining
by: Paola Francica, et al.
Published: (2020-08-01)

53BP1 integrates DNA repair and p53-dependent cell fate decisions via distinct mechanisms
by: Cuella-Martin, R, et al.
Published: (2016)

KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.
by: Yi-Hui Lin, et al.
Published: (2015-01-01)

Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ
by: Douglas R. Walker, et al.
Published: (2023-02-01)

RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.
by: Chapman, R, et al.
Published: (2013)

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
by: Ghezraoui, H, et al.
Published: (2018)

Shieldin and CST co-orchestrate DNA polymerase-dependent tailed-end joining reactions independently of 53BP1-governed repair pathway choice
by: King, A, et al.
Published: (2024)

Loss of CENP-I Impairs Homologous Recombination and Sensitizes Cells to PARP1 Inhibition
by: Tuyen T. Dang, et al.
Published: (2021-06-01)

Saccharomyces cerevisiae C1D is implicated in both non-homologous DNA end joining and homologous recombination.
by: Erdemir, T, et al.
Published: (2002)

Involvement of Caveolin-1 in repair of DNA damage through both homologous recombination and non-homologous end joining.
by: Hua Zhu, et al.
Published: (2010-08-01)

Correction: Comparative Molecular Docking Analysis of Cytoplasmic Dynein Light Chain DYNLL1 with Pilin to Explore the Molecular Mechanism of Pathogenesis Caused by PAO.
by: Samina Kausar, et al.
Published: (2013-01-01)

Structural insight into BLM recognition by TopBP1
by: Sun, L, et al.
Published: (2017)

The Non-Homologous End Joining Protein PAXX Acts to Restrict HSV-1 Infection
by: Ben J. Trigg, et al.
Published: (2017-11-01)

TRIM68, PIKFYVE, and DYNLL2: The Possible Novel Autophagy- and Immunity-Associated Gene Biomarkers for Osteosarcoma Prognosis
by: Jie Jiang, et al.
Published: (2021-04-01)

Mechanisms of PARP inhibitor resistance in cancer and insights into the DNA damage response
by: Paola Francica, et al.
Published: (2018-12-01)

Comparative molecular docking analysis of cytoplasmic dynein light chain DYNLL1 with pilin to explore the molecular mechanism of pathogenesis caused by Pseudomonas aeruginosa PAO.
by: Samina Kausar, et al.
Published: (2013-01-01)

Interactions of PARP1 Inhibitors with PARP1-Nucleosome Complexes
by: Natalya Maluchenko, et al.
Published: (2022-10-01)

BRCA1 Directs the Repair Pathway to Homologous Recombination by Promoting 53BP1 Dephosphorylation
by: Mayu Isono, et al.
Published: (2017-01-01)

Selective loss of PARG restores PARylation and counteracts PARP inhibitor-mediated synthetic lethality
by: Gogola, E, et al.
Published: (2018)

COM-1 promotes homologous recombination during Caenorhabditis elegans meiosis by antagonizing Ku-mediated non-homologous end joining.
by: Bennie B L G Lemmens, et al.
Published: (2013-01-01)

Loss of NFBD1/MDC1 disrupts homologous recombination repair and sensitizes nasopharyngeal carcinoma cells to PARP inhibitors
by: Zhihai Wang, et al.
Published: (2019-02-01)

Correction: Comparative Molecular Docking Analysis of Cytoplasmic Dynein Light Chain DYNLL1 with Pilin to Explore the Molecular Mechanism of Pathogenesis Caused by Pseudomonas aeruginosa PAO
Published: (2013-01-01)

Immunomodulatory Roles of PARP-1 and PARP-2: Impact on PARP-Centered Cancer Therapies
by: José Yélamos, et al.
Published: (2020-02-01)

Filling in the gaps in PARP inhibitor-induced synthetic lethality
by: Mariana Paes Dias, et al.
Published: (2021-11-01)

BARD1 reads H2A lysine 15 ubiquitination to direct homologous recombination
by: Becker, JR, et al.
Published: (2021)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks.
by: Couto, C, et al.
Published: (2011)

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks
by: Couto, C, et al.
Published: (2011)

PALB2 or BARD1 loss confers homologous recombination deficiency and PARP inhibitor sensitivity in prostate cancer
by: Kasia M. Dillon, et al.
Published: (2022-06-01)

IGF-1R inhibition enhances radiosensitivity and delays double-strand break repair by both non-homologous end-joining and homologous recombination.
by: Chitnis, M, et al.
Published: (2014)