The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers. Intra-chromosomal DNA double-strand break (DSB) joining events during immunoglobulin class switch recombination (CSR) require 53BP1. However, in BRCA...

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Detalhes bibliográficos
Principais autores:	Becker, JR, Cuella-Martin, R, Barazas, M, Liu, R, Oliveira, C, Oliver, AW, Bilham, K, Holt, AB, Blackford, AN, Heierhorst, J, Jonkers, J, Rottenberg, S, Chapman, JR
Formato:	Journal article
Publicado em:	Springer Nature 2018

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